Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 2/20 | 0.36 |
| ▸ | CA12 | O43570 | 1/20 | 0.36 |
| ▸ | CA7 | P43166 | 1/20 | 0.36 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.36 |
| ▸ | PTGES | O14684 | 1/20 | 0.35 |
| ▸ | AKT1 | P31749 | 2/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.35 |
| ▸ | CA2 | P00918 | 1/20 | 0.34 |
| ▸ | NPFFR1 | Q9GZQ6 | 2/20 | 0.34 |
| ▸ | NPFFR2 | Q9Y5X5 | 2/20 | 0.34 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.34 |
| ▸ | ATM | Q13315 | 1/20 | 0.34 |
| ▸ | AURKA | O14965 | 2/20 | 0.34 |
| ▸ | RPS6KB1 | P23443 | 2/20 | 0.34 |
| ▸ | NAMPT | P43490 | 1/20 | 0.33 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | APAF1 | O14727 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6681133 | 0.89 | NR1H4 (0.34) | CA1CA12MAPKAPK2NR1H4 | |
| SCHEMBL6679119 | 0.86 | NR1H4 (0.35) | CA1CA12CA2MAPKAPK2NR1H4 | |
| SCHEMBL6682103 | 0.86 | AKT1 (0.37) | PTGESAKT1HDAC1NPFFR1NPFFR2 | |
| SCHEMBL6679938 | 0.85 | NR1H4 (0.36) | CA1CA12CA2MAPKAPK2NR1H4 | |
| SCHEMBL6675974 | 0.84 | CA1 (0.36) | CA1CA12CA2MAPKAPK2NR1H4 | |
| SCHEMBL6678078 | 0.83 | MAPKAPK2 (0.36) | MAPKAPK2NR1H4MEN1KMT2A | |
| SCHEMBL6675630 | 0.83 | NR1H4 (0.35) | CA1CA12MAPKAPK2NR1H4CTSK | |
| SCHEMBL6681842 | 0.82 | CA1 (0.34) | CA1CA12CA7CA14HDAC1 | |
| SCHEMBL6675977 | 0.82 | NR1H4 (0.35) | CA1CA12CA2MAPKAPK2NR1H4 | |
| SCHEMBL6684393 | 0.81 | NR1H4 (0.34) | CA1CA12MAPKAPK2NR1H4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0798292-B1 | ANILINE DERIVATIVES HAVING NITROGEN MONOXIDE SYNTHASE INHIBITORY ACTIVITY | CHUGAI SEIYAKUKABUSHIKI KAISHA (JP) | 2004-11-03 | — | — | EP | disclosed |
| US-6534546-B1 | Guanidine- or isothioureido-N-derived anilines; brain, nervous system, and neurodegenerative disorders | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 2003-03-18 | — | — | US | disclosed |
| EP-0798292-A1 | ANILINE DERIVATIVES HAVING NITROGEN MONOXIDE SYNTHASE INHIBITORY ACTIVITY | Chugai Seiyaku Kabushiki Kaisha (JP) | 1997-10-01 | — | — | EP | disclosed |