Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ERN1 | O75460 | 7/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | IDO1 | P14902 | 1/20 | 0.36 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.36 |
| ▸ | EGFR | P00533 | 1/20 | 0.36 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.36 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.35 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.35 |
| ▸ | PRKDC | P78527 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | THRA | P10827 | 3/20 | 0.35 |
| ▸ | THRB | P10828 | 3/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3130670 | 0.86 | TRPV1 (0.44) | LMNAMAPTIDO1ALOX5TRPV1 | |
| SCHEMBL1302419 | 0.85 | HSP90AB1 (0.51) | ERN1LMNAMAPTHSP90AB1PRKDC | |
| SCHEMBL5072092 | 0.79 | TRPV1 (0.54) | MAPTALOX5TRPV1PTPN1GAA | |
| SCHEMBL3679438 | 0.79 | RPS6KA3 (0.39) | MAPTIDO1ALOX5TRPV1PTPN1 | |
| SCHEMBL3684924 | 0.79 | THRA (0.39) | MAPTIDO1ALOX5TRPV1HSP90AB1 | |
| SCHEMBL4930870 | 0.77 | TSHR (0.45) | TRPV1PTPN1HSP90AB1THRATHRB | |
| SCHEMBL30185945 | 0.77 | CDK1 (0.59) | ERN1ALOX5PTPN1GAA | |
| SCHEMBL15543678 | 0.77 | CDK1 (0.59) | ERN1ALOX5PTPN1GAA | |
| SCHEMBL18232227 | 0.76 | PTPN1 (0.43) | LMNAMAPTIDO1ALOX5PTPN1 | |
| SCHEMBL28131968 | 0.76 | TRPV1 (0.47) | LMNATRPV1HSP90AB1THRATHRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004062661-A1 | 2-‘5-(5-CARBAMIMIDOYL-1H-HETEROARYL)-6-HYDROXYBIPHENYL-3-YL!- CARBOXYLIC ACID DERIVATIVES AS FACTOR VIIA INHIBITORS | AXYS PHARMACEUTICALS, INC. (US) | 2004-07-29 | — | — | WO | disclosed |