Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.54 |
| ▸ | ALOX5 | P09917 | 5/20 | 0.52 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.49 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.48 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.48 |
| ▸ | RELA | Q04206 | 1/20 | 0.48 |
| ▸ | TNKS2 | Q9H2K2 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | GAA | P10253 | 2/20 | 0.46 |
| ▸ | USP2 | O75604 | 1/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.46 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | OR51E2 | Q9H255 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.43 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL490925 | 0.89 | ALOX5 (0.62) | ALOX5NFKB1NFKB2RELATNKS2 | |
| SCHEMBL3130670 | 0.89 | TRPV1 (0.44) | TRPV1ALOX5MAPTKMT2AALDH1A1 | |
| SCHEMBL3681959 | 0.87 | ALOX5 (0.55) | TRPV1ALOX5PTGS2TNKS2MAPT | |
| SCHEMBL14311297 | 0.86 | ALOX5 (0.56) | TRPV1ALOX5PTGS2NFKB1NFKB2 | |
| SCHEMBL1525224 | 0.84 | HSP90AB1 (0.54) | TRPV1ALOX5PTGS2MAPTKMT2A | |
| SCHEMBL28853057 | 0.82 | TRPV1 (0.54) | TRPV1ALOX5NFKB1NFKB2RELA | |
| SCHEMBL3684924 | 0.82 | THRA (0.39) | TRPV1ALOX5MAPT | |
| SCHEMBL11213629 | 0.82 | ALOX5 (0.52) | ALOX5NFKB1NFKB2RELATNKS2 | |
| SCHEMBL3679438 | 0.82 | RPS6KA3 (0.39) | TRPV1ALOX5MAPTKMT2AALDH1A1 | |
| SCHEMBL16294204 | 0.80 | ALOX5 (0.54) | ALOX5MAPTKMT2AMEN1OR51E2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7319163-B2 | Thyroid receptor antagonists for the treatment of cardiac and metabolic disorders | KARO BIO AB (SE) | 2008-01-15 | — | — | US | disclosed |
| US-7005538-B1 | Thyroid receptor antagonists for the treatment of cardiac and metabolic disorders | KARO BIO AB (SE) | 2006-02-28 | — | — | US | disclosed |
| US-20050267206-A1 | Thyroid receptor antagonists for the treatment of cardiac and metabolic disorders | MALM JOHAN | 2005-12-01 | — | — | US | disclosed |
| WO-2001036365-A2 | THYROID RECEPTOR ANTAGONISTS FOR THE TREATMENT OF CARDIAC AND METABOLIC DISORDERS | KARO BIO AB (SE) | 2001-05-25 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050267206-A1 | Thyroid receptor antagonists for the treatment of cardiac and metabolic disorders | TSHR, THRB, THRA | TRPV1 331/4885ALOX5 2020/4885PTGS2 2771/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.