Known targets — ChEMBL curated mechanism
ADRB1CDK4CDK6CHRM2CHRM3DPP4DRD2DRD3DRD4EGFRHRH1HTR1BHTR1DHTR1FHTR2AHTR2CHTR4SLC6A2SLC6A4
The experimentally established mechanism targets of Succinic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | ALKBH5 | Q6P6C2 | 1/20 | 0.43 |
| ▸ | SUCNR1 | Q9BXA5 | 1/20 | 0.43 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.43 |
| ▸ | FFAR3 | O14843 | 1/20 | 0.42 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.42 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.42 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.42 |
| ▸ | SLC15A2 | Q16348 | 1/20 | 0.40 |
| ▸ | CAMK2A | Q9UQM7 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
| ▸ | GPR84 | Q9NQS5 | 8/20 | 0.37 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.37 |
| ▸ | FFAR4 | Q5NUL3 | 2/20 | 0.37 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Succinic Acid SCHEMBL28597264 | 1.00 | LMNA (0.43) | LMNAALKBH5SUCNR1EGLN1FFAR3 | |
| Succinic Acid SCHEMBL542105 | 0.95 | LMNA (0.47) | LMNAALKBH5SUCNR1EGLN1FFAR3 | |
| Adipic Acid SCHEMBL27794616 | 0.91 | GPR84 (0.50) | LMNACAMK2AALDH1A1MEN1KMT2A | |
| SCHEMBL29793964 | 0.91 | FFAR3 (0.42) | LMNAALKBH5SUCNR1EGLN1FFAR3 | |
| Succinic Acid SCHEMBL28327661 | 0.88 | TSHR (0.38) | LMNAALKBH5SUCNR1EGLN1FFAR3 | |
| Adipic Acid SCHEMBL28306897 | 0.87 | GPR84 (0.58) | LMNACAMK2AALDH1A1MEN1KMT2A | |
| Adipic Acid SCHEMBL7761237 | 0.86 | AKR1B1 (0.54) | LMNAALDH1A1MEN1KMT2AGPR84 | |
| Adipic Acid SCHEMBL536473 | 0.86 | AKR1B1 (0.54) | LMNAALDH1A1MEN1KMT2AGPR84 | |
| Adipic Acid SCHEMBL536500 | 0.86 | AKR1B1 (0.54) | LMNAALDH1A1MEN1KMT2AGPR84 | |
| Butyric Acid SCHEMBL813982 | 0.86 | FFAR3 (0.62) | FFAR3HDAC3HDAC1HDAC2HDAC8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110452360-B | Strong-polarity branched polyurethane elastomer for 75A-hardness silk screen scraper and preparation method thereof | 淄博华天橡塑科技有限公司 | 2021-06-04 | — | — | CN | disclosed |
| EP-0747416-B1 | ALIPHATIC POLYESTER RESIN AND PROCESS FOR PRODUCING THE SAME | SHOWA DENKO KK (JP) | 2004-11-10 | — | — | EP | disclosed |
| US-5714569-A | IMPROVED FORMABILITY, STABILITY, BIODEGRADATION | SHOWA DENKO K.K. (JP) | 1998-02-03 | — | — | US | disclosed |
| EP-0747416-A1 | ALIPHATIC POLYESTER RESIN AND PROCESS FOR PRODUCING THE SAME | SHOWA DENKO KABUSHIKI KAISHA (JP) | 1996-12-11 | — | — | EP | disclosed |