Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 10/20 | 0.70 |
| ▸ | RAB9A | P51151 | 9/20 | 0.70 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.70 |
| ▸ | MAPT | P10636 | 6/20 | 0.70 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.70 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.70 |
| ▸ | HPGD | P15428 | 4/20 | 0.70 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.58 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.58 |
| ▸ | RELA | Q04206 | 1/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.56 |
| ▸ | MEN1 | O00255 | 5/20 | 0.56 |
| ▸ | GAA | P10253 | 2/20 | 0.56 |
| ▸ | GLA | P06280 | 1/20 | 0.56 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.54 |
| ▸ | APBA1 | Q02410 | 1/20 | 0.54 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.51 |
| ▸ | TP53 | P04637 | 1/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.51 |
| ▸ | UTRN | P46939 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6681353 | 0.88 | NPC1 (0.70) | NPC1RAB9AKDM4EMAPTSMN1; SMN2 | |
| SCHEMBL29363950 | 0.88 | NPC1 (0.78) | NPC1RAB9AKDM4EMAPTSMN1; SMN2 | |
| SCHEMBL2268609 | 0.88 | NPC1 (0.78) | NPC1RAB9AKDM4EMAPTSMN1; SMN2 | |
| SCHEMBL12209706 | 0.84 | NPC1 (0.72) | NPC1RAB9AKDM4EMAPTSMN1; SMN2 | |
| SCHEMBL24454865 | 0.83 | NPC1 (0.76) | NPC1RAB9AKDM4EMAPTSMN1; SMN2 | |
| SCHEMBL16424489 | 0.83 | NPC1 (0.75) | NPC1RAB9AKDM4EMAPTSMN1; SMN2 | |
| SCHEMBL30296291 | 0.83 | NPC1 (0.75) | NPC1RAB9AKDM4EMAPTSMN1; SMN2 | |
| SCHEMBL12209714 | 0.83 | NPC1 (0.70) | NPC1RAB9AKDM4EMAPTSMN1; SMN2 | |
| SCHEMBL28028562 | 0.83 | SMN1; SMN2 (0.57) | NPC1RAB9AKDM4EMAPTSMN1; SMN2 | |
| SCHEMBL2494171 | 0.82 | NPC1 (1.00) | NPC1RAB9AKDM4EMAPTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004067480-A2 | SUBSTITUTED PHENYLUREA DERIVATIVES AS HDAC INHIBITORS | OXFORD GLYCOSCIENCES (UK) LTD (GB) | 2004-08-12 | — | — | WO | disclosed |
| WO-2004067480-A2 | SUBSTITUTED PHENYLUREA DERIVATIVES AS HDAC INHIBITORS | OXFORD GLYCOSCIENCES (UK) LTD (GB) | 2004-08-12 | — | — | WO | disclosed |