SCHEMBL6683153

SCHEMBL6683153

Nc1c(Cl)c(Cl)cc2nc(Cl)c(Cl)nc12

nearest known ligand 0.34

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
TDP1 Q9NUW8 1/20 0.34
ACHE P22303 1/20 0.33
CASP6 P55212 1/20 0.32
ALDH1A1 P00352 1/20 0.31
CYP3A4 P08684 1/20 0.31
GLP1R P43220 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29162274 0.80 CYP3A4 (0.39) TDP1ALDH1A1CYP3A4
SCHEMBL7478802 0.80 GRIN2D (0.35) TDP1ACHECASP6GLP1R
SCHEMBL7476392 0.80 ALDH1A1 (0.36) TDP1ACHEALDH1A1CYP3A4
SCHEMBL7467279 0.80 TDP1 (0.32) TDP1ACHECASP6
SCHEMBL7469027 0.80 KHK (0.33) TDP1
SCHEMBL6680601 0.76 HRH4 (0.38) ACHEGLP1R
SCHEMBL7465708 0.76 GAA (0.34) ALDH1A1GLP1R
SCHEMBL7466809 0.76 POLB (0.30)
SCHEMBL7474557 0.75 TDP1 (0.34) TDP1CYP3A4
SCHEMBL7472208 0.72 TDP1 (0.32) TDP1ACHEALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0973766-B1 QUINOXALINEDIONES PFIZER LTD (GB) 2004-11-17 EP disclosed
CN-1103770-C Quinoxalinediones PFIZER RES AND DEV CO N V S A (IE) 2003-03-26 CN disclosed
US-6376490-B1 STRONG N-METHYL-D-ASPARATE RECEPTOR ANTAGONISTS; USEFUL IN TREATING STROKES, ISCHEMIA, AND CENTRAL NERVOUS SYSTEM INJURIES PFIZER INC 2002-04-23 US disclosed
EP-0783495-B1 QUINOXALINE DERIVATIVES USEFUL IN THERAPY PFIZER LTD (GB) 2002-02-27 EP disclosed
US-6333326-B1 FOR THERAPY OF NEURODEGENERATIVE DISEASES SELECTED FROM STROKE, TRANSIENT ISCHEMIC ATTACK, PERI-OPERATIVE ISCHAEMIA, GLOBAL ISCHAEMIA FOLLOWING CARDIAC ARREST, AND TRAUMATIC HEAD INJURY TO BRAIN OR SPINAL CORD, EPILEPSY PFIZER INC 2001-12-25 US disclosed
EP-0885212-B1 QUINOXALINEDIONES PFIZER RES AND BR DEV COMPANY (IE) 2001-11-14 EP disclosed
EP-0781279-B1 QUINOXALINEDIONE NMDA RECEPTOR ANTAGONISTS PFIZER LTD (GB) 2001-06-13 EP disclosed
EP-0973766-A1 QUINOXALINEDIONES Pfizer Limited (GB) 2000-01-26 EP disclosed
CN-1213369-A Quinoxalinedione compound PFIZER RES & DEV (IE) 1999-04-07 CN disclosed
US-5863917-A ANXIOLYTIC AGENT, ANTICONVULSANTS, ANALGESICS AND NEUROPROTECTIVES. PFIZER, INC. (US) 1999-01-26 US disclosed
US-5852016-A Quinoxaline derivatives useful in therapy PFIZER INC. (US) 1998-12-22 US disclosed
WO-1998038186-A1 QUINOXALINEDIONES PFIZER LIMITED (GB) 1998-09-03 WO disclosed
US-5783572-A TREATMENT OF NEURODEGENERATIVE DISORDERS PFIZER INC. (US) 1998-07-21 US disclosed
WO-1997032873-A1 QUINOXALINEDIONES PFIZER RESEARCH AND DEVELOPMENT COMPANY, N.V./S.A. (IE) 1997-09-12 WO disclosed
EP-0792874-A1 Quinoxaline derivatives useful in therapy Pfizer Limited (GB) 1997-09-03 EP disclosed
CN-1158610-A Quinoxaline derivatives useful in therapy PFIZER LTD (IE) 1997-09-03 CN disclosed
EP-0783495-A1 QUINOXALINE DERIVATIVES USEFUL IN THERAPY Pfizer Limited (GB) 1997-07-16 EP disclosed
EP-0781279-A1 QUINOXALINEDIONE NMDA RECEPTOR ANTAGONISTS Pfizer Limited (GB) 1997-07-02 EP disclosed
WO-1996009295-A1 QUINOXALINE DERIVATIVES USEFUL IN THERAPY PFIZER LIMITED (GB) 1996-03-28 WO disclosed
WO-1996008485-A1 QUINOXALINEDIONE NMDA RECEPTOR ANTAGONISTS PFIZER LIMITED (GB) 1996-03-21 WO disclosed