Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | ACHE | P22303 | 1/20 | 0.31 |
| ▸ | KHK | P50053 | 1/20 | 0.30 |
| ▸ | CASP6 | P55212 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6683153 | 0.80 | TDP1 (0.34) | TDP1ACHECASP6 | |
| SCHEMBL7465264 | 0.78 | HRH4 (0.36) | — | |
| SCHEMBL7469027 | 0.77 | KHK (0.33) | TDP1KHK | |
| SCHEMBL7478802 | 0.77 | GRIN2D (0.35) | TDP1ACHECASP6 | |
| SCHEMBL7465708 | 0.73 | GAA (0.34) | — | |
| SCHEMBL7471483 | 0.70 | ALDH1A1 (0.39) | TDP1CASP6 | |
| SCHEMBL28558287 | 0.69 | TDP1 (0.36) | TDP1 | |
| SCHEMBL7472208 | 0.69 | TDP1 (0.32) | TDP1ACHE | |
| SCHEMBL7476392 | 0.69 | ALDH1A1 (0.36) | TDP1ACHE | |
| SCHEMBL7470290 | 0.69 | SMN1; SMN2 (0.37) | TDP1ACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0783495-B1 | QUINOXALINE DERIVATIVES USEFUL IN THERAPY | PFIZER LTD (GB) | 2002-02-27 | — | — | EP | disclosed |
| US-5852016-A | Quinoxaline derivatives useful in therapy | PFIZER INC. (US) | 1998-12-22 | — | — | US | disclosed |
| EP-0783495-A1 | QUINOXALINE DERIVATIVES USEFUL IN THERAPY | Pfizer Limited (GB) | 1997-07-16 | — | — | EP | disclosed |
| WO-1996009295-A1 | QUINOXALINE DERIVATIVES USEFUL IN THERAPY | PFIZER LIMITED (GB) | 1996-03-28 | — | — | WO | disclosed |