Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Aspartic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC1A1 | P43005 | 6/20 | 0.47 |
| ▸ | LTA4H | P09960 | 3/20 | 0.44 |
| ▸ | ALPI | P09923 | 1/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.44 |
| ▸ | XIAP | P98170 | 1/20 | 0.44 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.44 |
| ▸ | GRIK1 | P39086 | 3/20 | 0.44 |
| ▸ | PPARG | P37231 | 1/20 | 0.43 |
| ▸ | PPARA | Q07869 | 1/20 | 0.43 |
| ▸ | SLC1A3 | P43003 | 5/20 | 0.42 |
| ▸ | SLC1A2 | P43004 | 4/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | SLC15A1 | P46059 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Succinic Acid SCHEMBL6684048 | 0.81 | ALDH1A1 (0.44) | PKMPPARGPPARAKMT2AMEN1 | |
| SCHEMBL211957 | 0.79 | NPC1 (0.46) | PPARGPPARAKMT2AMEN1SMN1; SMN2 | |
| SCHEMBL14006337 | 0.79 | NPC1 (0.46) | PPARGPPARAKMT2AMEN1SMN1; SMN2 | |
| SCHEMBL134049 | 0.79 | NPC1 (0.46) | PPARGPPARAKMT2AMEN1SMN1; SMN2 | |
| Maleic Acid SCHEMBL6688994 | 0.78 | HCAR2 (0.56) | PKMPPARGPPARAKMT2AMEN1 | |
| Fumaric Acid SCHEMBL6689002 | 0.78 | HCAR2 (0.56) | PKMPPARGPPARAKMT2AMEN1 | |
| Maleic Acid SCHEMBL6688997 | 0.78 | HCAR2 (0.56) | PKMPPARGPPARAKMT2AMEN1 | |
| Aspartic Acid SCHEMBL27570549 | 0.75 | SLC7A5 (0.56) | SLC1A1ALPIPKMPTGS1XIAP | |
| Aspartic Acid SCHEMBL7781975 | 0.74 | GRIK1 (0.61) | SLC1A1ALPIPKMPTGS1XIAP | |
| Aspartic Acid SCHEMBL10903594 | 0.73 | ALDH1A1 (0.68) | SLC1A1LTA4HALPIPKMPTGS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004069145-A2 | ANTICANCER COMPOUNDS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | DR. REDDY'S LABORATORIES LTD. (IN) | 2004-08-19 | — | — | WO | disclosed |