Known targets — ChEMBL curated mechanism
ADRB1CDK4CDK6CHRM2CHRM3DPP4DRD2DRD3DRD4EGFRHRH1HTR1BHTR1DHTR1FHTR2AHTR2CHTR4SLC6A2SLC6A4
The experimentally established mechanism targets of Succinic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.44 |
| ▸ | FFAR1 | O14842 | 3/20 | 0.44 |
| ▸ | FFAR4 | Q5NUL3 | 2/20 | 0.44 |
| ▸ | PPARG | P37231 | 1/20 | 0.43 |
| ▸ | PPARA | Q07869 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.42 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.42 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.42 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL211957 | 0.88 | NPC1 (0.46) | ALDH1A1PPARGPPARAMEN1NPC1 | |
| SCHEMBL134049 | 0.88 | NPC1 (0.46) | ALDH1A1PPARGPPARAMEN1NPC1 | |
| SCHEMBL14006337 | 0.88 | NPC1 (0.46) | ALDH1A1PPARGPPARAMEN1NPC1 | |
| Maleic Acid SCHEMBL6688997 | 0.87 | HCAR2 (0.56) | ALDH1A1PPARGPPARAMEN1NPC1 | |
| Maleic Acid SCHEMBL6688994 | 0.87 | HCAR2 (0.56) | ALDH1A1PPARGPPARAMEN1NPC1 | |
| Fumaric Acid SCHEMBL6689002 | 0.87 | HCAR2 (0.56) | ALDH1A1PPARGPPARAMEN1NPC1 | |
| Aspartic Acid SCHEMBL6683527 | 0.81 | SLC1A1 (0.47) | PPARGPPARAMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL9899924 | 0.76 | ALDH1A1 (0.52) | ALDH1A1PPARGPPARAMEN1NPC1 | |
| SCHEMBL9899925 | 0.76 | ALDH1A1 (0.52) | ALDH1A1PPARGPPARAMEN1NPC1 | |
| SCHEMBL14269412 | 0.76 | ALDH1A1 (0.51) | ALDH1A1PPARGPPARAMEN1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004069145-A2 | ANTICANCER COMPOUNDS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | DR. REDDY'S LABORATORIES LTD. (IN) | 2004-08-19 | — | — | WO | disclosed |