SCHEMBL6683972

SCHEMBL6683972

CC(=O)C1=C(C)NC(=O)N(C(=O)O)C1c1ccc(F)c(F)c1

nearest known ligand 0.49

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
ADRA1D P25100 19/20 0.49
ADRA1A P35348 19/20 0.49
ADRA1B P35368 19/20 0.49
TSHR P16473 1/20 0.43
NPSR1 Q6W5P4 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6714064 0.87 ADRA1D (0.47) ADRA1DADRA1AADRA1BTSHRNPSR1
SCHEMBL3991000 0.81 ADRA1D (0.61) ADRA1DADRA1AADRA1B
SCHEMBL6715576 0.77 CACNA1F (0.48) ADRA1DADRA1AADRA1B
SCHEMBL7660734 0.76 ADRA1D (0.42) ADRA1DADRA1AADRA1B
SCHEMBL5662048 0.75 ADRA1A (0.51) ADRA1DADRA1AADRA1B
SCHEMBL7082392 0.73 ADRA1A (0.61) ADRA1DADRA1AADRA1B
SCHEMBL7662607 0.71 ADRA1D (0.53) ADRA1DADRA1AADRA1B
SCHEMBL6715263 0.71 ADRA1D (0.60) ADRA1DADRA1AADRA1B
SCHEMBL13939624 0.70 ADRA1D (0.70) ADRA1DADRA1AADRA1B
SCHEMBL6201215 0.70 ADRA1D (0.65) ADRA1DADRA1AADRA1B

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2004064774-A2 DNA ENCODING A HUMAN MELANIN CONCENTRATING HORMONE RECEPTOR (MCH1) AND USES THEREOF SYNAPTIC PHARMACEUTICAL CORPORATION (US) 2004-08-05 WO disclosed