Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GFER | P55789 | 1/20 | 0.68 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.67 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.67 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.67 |
| ▸ | CASP1 | P29466 | 1/20 | 0.67 |
| ▸ | CASP7 | P55210 | 1/20 | 0.67 |
| ▸ | MAPT | P10636 | 7/20 | 0.55 |
| ▸ | PARP14 | Q460N5 | 1/20 | 0.53 |
| ▸ | TP53 | P04637 | 4/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | PIM1 | P11309 | 1/20 | 0.45 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.45 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.45 |
| ▸ | USP2 | O75604 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | IKBKB | O14920 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6624747 | 0.99 | GFER (0.70) | GFERALOX15MAPK1HSD17B10CASP1 | |
| SCHEMBL12764968 | 0.85 | GFER (0.49) | GFERALOX15MAPK1HSD17B10CASP1 | |
| SCHEMBL6683286 | 0.83 | GFER (0.97) | GFERALOX15MAPK1HSD17B10CASP1 | |
| SCHEMBL30561947 | 0.83 | NISCH (0.57) | GFERALOX15MAPK1HSD17B10CASP1 | |
| SCHEMBL29264060 | 0.83 | NISCH (0.57) | GFERALOX15MAPK1HSD17B10CASP1 | |
| SCHEMBL30317424 | 0.81 | GFER (1.00) | GFERALOX15MAPK1HSD17B10CASP1 | |
| SCHEMBL3941869 | 0.81 | GFER (1.00) | GFERALOX15MAPK1HSD17B10CASP1 | |
| SCHEMBL12764963 | 0.81 | GFER (0.47) | GFERALOX15MAPK1HSD17B10CASP1 | |
| SCHEMBL4586298 | 0.80 | GFER (0.76) | GFERALOX15MAPK1HSD17B10CASP1 | |
| SCHEMBL150478 | 0.80 | ALOX15 (1.00) | GFERALOX15MAPK1HSD17B10CASP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004063156-A1 | NOVEL INDOLE DERIVATES AS FABP-4 INHIBITORS | BIOVITRUM AB (SE) | 2004-07-29 | — | — | WO | claimed |
| US-20140363522-A1 | Compositions and Methods for Treating and/or Preventing Cancer by Inhibiting Fatty Acid Binding Proteins | NIH - DEITR | 2014-12-11 | — | — | US | disclosed |
| US-8748470-B2 | Methods for treating ovarian cancer by inhibiting fatty acid binding proteins | THE UNIVERSITY OF CHICAGO (US) | 2014-06-10 | — | — | US | disclosed |
| US-20120289570-A1 | COMPOSITIONS AND METHODS FOR TREATING AND/OR PREVENTING CANCER BY INHIBITING FATTY ACID BINDING PROTEINS | NIH | 2012-11-15 | — | — | US | disclosed |
| WO-2004063156-A1 | NOVEL INDOLE DERIVATES AS FABP-4 INHIBITORS | BIOVITRUM AB (SE) | 2004-07-29 | — | — | WO | disclosed |