Known targets — ChEMBL curated mechanism
ADORA1ADORA2AADORA2BADORA3PDE3APDE3BPDE4APDE4BPDE4CPDE4D
The experimentally established mechanism targets of Glycine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | MAOA | P21397 | 1/20 | 0.39 |
| ▸ | MAOB | P27338 | 1/20 | 0.39 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | TSHR | P16473 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | CA12 | O43570 | 2/20 | 0.34 |
| ▸ | CA1 | P00915 | 2/20 | 0.34 |
| ▸ | CA7 | P43166 | 1/20 | 0.34 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.34 |
| ▸ | CTSS | P25774 | 2/20 | 0.34 |
| ▸ | CTSK | P43235 | 2/20 | 0.34 |
| ▸ | CA2 | P00918 | 1/20 | 0.34 |
| ▸ | CA9 | Q16790 | 1/20 | 0.34 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL262291 | 0.89 | TDP1 (0.47) | KMT2AMEN1GAATDP1MAOA | |
| Glycine SCHEMBL5171360 | 0.79 | MEN1 (0.37) | KMT2AMEN1GAATDP1MAOA | |
| SCHEMBL6690077 | 0.78 | SYK (0.50) | KMT2AMEN1MAPTCA12CA1 | |
| SCHEMBL24503819 | 0.77 | TDP1 (0.40) | KMT2AMEN1GAATDP1MAOA | |
| SCHEMBL9300578 | 0.75 | TSHR (0.39) | KMT2AMEN1GAATDP1MAPT | |
| SCHEMBL4893443 | 0.75 | TDP1 (0.49) | KMT2AMEN1GAATDP1MAOA | |
| SCHEMBL8775013 | 0.74 | TDP1 (0.47) | KMT2AMEN1GAATDP1MAOA | |
| SCHEMBL2404127 | 0.74 | TDP1 (0.50) | KMT2AMEN1GAATDP1MAOA | |
| SCHEMBL18487257 | 0.74 | TDP1 (0.50) | KMT2AMEN1GAATDP1MAOA | |
| SCHEMBL18262007 | 0.74 | TDP1 (0.50) | KMT2AMEN1GAATDP1MAOA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004074316-A1 | CONFORMATIONALLY CONSTRAINED BACKBONE CYCLIZED PEPTIDE ANALOGS | GILON CHAIM (IL) | 2004-09-02 | — | — | WO | claimed |
| WO-2004074316-A1 | CONFORMATIONALLY CONSTRAINED BACKBONE CYCLIZED PEPTIDE ANALOGS | GILON CHAIM (IL) | 2004-09-02 | — | — | WO | disclosed |
| EP-0804468-A1 | CONFORMATIONALLY CONSTRAINED BACKBONE CYCLIZED PEPTIDE ANALOG | PEPTOR LTD (IL) | 1997-11-05 | — | — | EP | disclosed |
| WO-1995033765-A1 | CONFORMATIONALLY CONSTRAINED BACKBONE CYCLIZED PEPTIDE ANALOG | PEPTOR LTD. (IL) | 1995-12-14 | — | — | WO | disclosed |