Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.41 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.39 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.39 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | TAS1R3 | Q7RTX0 | 2/20 | 0.38 |
| ▸ | TAS1R1 | Q7RTX1 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | SNCA | P37840 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3773374 | 0.84 | TDP1 (0.49) | TDP1L3MBTL1KMT2AHDAC2HDAC3 | |
| SCHEMBL1120204 | 0.79 | SMN1; SMN2 (0.43) | TDP1L3MBTL1KMT2AALDH1A1MAPT | |
| SCHEMBL6047114 | 0.79 | TDP1 (0.42) | TDP1L3MBTL1KMT2AHDAC2HDAC3 | |
| SCHEMBL2133980 | 0.79 | KMT2A (0.46) | L3MBTL1KMT2AHDAC1ALDH1A1MAPT | |
| SCHEMBL1083105 | 0.78 | TDP1 (0.43) | TDP1L3MBTL1KMT2AHDAC2HDAC3 | |
| SCHEMBL10565579 | 0.76 | AKT1 (0.49) | TDP1L3MBTL1KMT2AALDH1A1MAPT | |
| SCHEMBL2685210 | 0.73 | GPR119 (0.43) | L3MBTL1KMT2AHDAC2HDAC3HDAC1 | |
| SCHEMBL2132839 | 0.72 | CYP2C9 (0.49) | KMT2AHDAC2HDAC3HDAC1NCOR2 | |
| SCHEMBL1061630 | 0.71 | F10 (0.48) | L3MBTL1KMT2AHDAC2HDAC1ALDH1A1 | |
| Styrene SCHEMBL28236128 | 0.70 | ALDH1A1 (0.54) | TDP1KMT2AALDH1A1MAPTNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1429765-A2 | INHIBITORS OF HISTONE DEACETYLASE | Methylgene, Inc. (CA) | 2004-06-23 | — | — | EP | disclosed |
| WO-2003024448-A2 | INHIBITORS OF HISTONE DEACETYLASE | METHYLGENE, INC. (CA) | 2003-03-27 | — | — | WO | disclosed |