Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.66 |
| ▸ | POLB | P06746 | 1/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.57 |
| ▸ | LMNA | P02545 | 2/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.57 |
| ▸ | MEN1 | O00255 | 1/20 | 0.57 |
| ▸ | F2 | P00734 | 1/20 | 0.57 |
| ▸ | TSHR | P16473 | 1/20 | 0.57 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.57 |
| ▸ | GRM5 | P41594 | 4/20 | 0.56 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.55 |
| ▸ | NPC1 | O15118 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.55 |
| ▸ | HPGD | P15428 | 1/20 | 0.55 |
| ▸ | RAB9A | P51151 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6678495 | 0.85 | SMN1; SMN2 (0.56) | MAPTPOLBSMN1; SMN2KMT2ALMNA | |
| SCHEMBL2850317 | 0.78 | KDM1A (0.58) | MAPTPOLBSMN1; SMN2KMT2ALMNA | |
| SCHEMBL6680339 | 0.76 | ADORA3 (0.66) | MAPTSMN1; SMN2KMT2ALMNAKDM4E | |
| SCHEMBL5924065 | 0.73 | SMN1; SMN2 (0.51) | MAPTSMN1; SMN2KMT2ALMNAKDM4E | |
| SCHEMBL6681714 | 0.73 | ADORA3 (0.61) | MAPTSMN1; SMN2KMT2ALMNAKDM4E | |
| SCHEMBL2482825 | 0.72 | GRM5 (1.00) | LMNAGRM5 | |
| SCHEMBL26855253 | 0.72 | MAPT (0.65) | MAPTPOLBSMN1; SMN2KMT2AMEN1 | |
| SCHEMBL5924153 | 0.72 | KDM1A (0.52) | MAPTPOLBSMN1; SMN2KMT2ALMNA | |
| SCHEMBL10061505 | 0.71 | POLB (0.62) | MAPTPOLBSMN1; SMN2LMNAGRM5 | |
| SCHEMBL5924283 | 0.71 | GRM5 (1.00) | MAPTLMNAGRM5ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004043951-A1 | PYRAZOLE DERIVATIVES AS MODULATORS OF PEROXISOME PROLIFERATOR ACTIVATED RECEPTORS | CAREX S.A. (FR) | 2004-05-27 | — | — | WO | claimed |
| WO-2004043951-A1 | PYRAZOLE DERIVATIVES AS MODULATORS OF PEROXISOME PROLIFERATOR ACTIVATED RECEPTORS | CAREX S.A. (FR) | 2004-05-27 | — | — | WO | disclosed |