Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSS | P25774 | 1/20 | 0.43 |
| ▸ | CTSK | P43235 | 1/20 | 0.43 |
| ▸ | KCNQ4 | P56696 | 3/20 | 0.40 |
| ▸ | KCNQ5 | Q9NR82 | 3/20 | 0.40 |
| ▸ | PDE6D | O43924 | 1/20 | 0.38 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.38 |
| ▸ | PSEN1 | P49768 | 4/20 | 0.37 |
| ▸ | PSEN2 | P49810 | 4/20 | 0.37 |
| ▸ | APH1B | Q8WW43 | 4/20 | 0.37 |
| ▸ | NCSTN | Q92542 | 4/20 | 0.37 |
| ▸ | APH1A | Q96BI3 | 4/20 | 0.37 |
| ▸ | PSENEN | Q9NZ42 | 4/20 | 0.37 |
| ▸ | TSHR | P16473 | 2/20 | 0.37 |
| ▸ | CA12 | O43570 | 1/20 | 0.37 |
| ▸ | CA2 | P00918 | 1/20 | 0.37 |
| ▸ | CA7 | P43166 | 1/20 | 0.37 |
| ▸ | CA9 | Q16790 | 1/20 | 0.37 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5064260 | 0.78 | CTSS (0.44) | CTSSCTSKKCNQ4KCNQ5CACNA1B | |
| SCHEMBL7147027 | 0.78 | CTSS (0.44) | CTSSCTSKKCNQ4KCNQ5CACNA1B | |
| SCHEMBL5060017 | 0.78 | CTSS (0.44) | CTSSCTSKKCNQ4KCNQ5CACNA1B | |
| SCHEMBL6075777 | 0.78 | CTSS (0.44) | CTSSCTSKKCNQ4KCNQ5CACNA1B | |
| SCHEMBL5055741 | 0.78 | CTSS (0.44) | CTSSCTSKKCNQ4KCNQ5CACNA1B | |
| SCHEMBL5064577 | 0.78 | CTSS (0.44) | CTSSCTSKKCNQ4KCNQ5CACNA1B | |
| SCHEMBL6835198 | 0.78 | CTSS (0.44) | CTSSCTSKKCNQ4KCNQ5CACNA1B | |
| SCHEMBL15382445 | 0.78 | CACNA1B (0.39) | CTSSCACNA1BPSEN1PSEN2APH1B | |
| SCHEMBL13396256 | 0.78 | CTSS (0.50) | CTSSCTSKPSEN1PSEN2APH1B | |
| SCHEMBL27603663 | 0.77 | CTSS (0.47) | CTSSCTSKKCNQ4KCNQ5TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1438298-A1 | PIPERAZINE DERIVATIVES WITH CCR1 RECEPTOR ANTAGONIST ACTIVITY | Pfizer Products Inc. (US) | 2004-07-21 | — | — | EP | disclosed |
| WO-2003035627-A1 | PIPERAZINE DERIVATIVES WITH CCR1 RECEPTOR ANTAGONIST ACTIVITY | PFIZER PRODUCTS INC. (US) | 2003-05-01 | — | — | WO | disclosed |