Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 7/20 | 0.67 |
| ▸ | PTPN2 | P17706 | 2/20 | 0.46 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | GFER | P55789 | 1/20 | 0.37 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.36 |
| ▸ | GHSR | Q92847 | 1/20 | 0.35 |
| ▸ | HTR6 | P50406 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6687346 | 0.99 | PTPN1 (0.66) | PTPN1PTPN2GAAKDM4ETDP1 | |
| SCHEMBL6687344 | 0.97 | PTPN1 (0.65) | PTPN1PTPN2GAAKDM4ETDP1 | |
| SCHEMBL6684915 | 0.84 | PTPN1 (0.67) | PTPN1PTPN2KDM4EALDH1A1MEN1 | |
| SCHEMBL6688145 | 0.81 | PTPN1 (0.63) | PTPN1PTPN2 | |
| SCHEMBL17898476 | 0.81 | PTPN1 (1.00) | PTPN1PTPN2MEN1KMT2AHTR6 | |
| SCHEMBL4643306 | 0.79 | PTPN1 (0.53) | PTPN1PTPN2ALDH1A1 | |
| SCHEMBL4646374 | 0.79 | PTPN1 (0.60) | PTPN1PTPN2 | |
| SCHEMBL6841900 | 0.79 | PTPN1 (0.71) | PTPN1PTPN2 | |
| SCHEMBL1732384 | 0.77 | PTPN1 (0.64) | PTPN1PTPN2GAAKDM4EALDH1A1 | |
| SCHEMBL17902653 | 0.77 | GAA (0.41) | PTPN1GAAKDM4ETDP1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004041799-A1 | 5- (SUBSTITUTED PHENYL) -THIADIAZOLIDINE-3-ONES AND THEIR USE AS PTP1B | ASTRAZENECA AB (SE) | 2004-05-21 | — | — | WO | disclosed |