Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 6/20 | 0.71 |
| ▸ | GRM5 | P41594 | 5/20 | 0.38 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.38 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.36 |
| ▸ | DRD2 | P14416 | 2/20 | 0.36 |
| ▸ | DRD4 | P21917 | 2/20 | 0.36 |
| ▸ | DRD3 | P35462 | 2/20 | 0.36 |
| ▸ | SRD5A1 | P18405 | 1/20 | 0.36 |
| ▸ | HAO1 | Q9UJM8 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17898476 | 0.83 | PTPN1 (1.00) | PTPN1PTPN2DRD2DRD4DRD3 | |
| SCHEMBL6685010 | 0.79 | PTPN1 (0.67) | PTPN1PTPN2 | |
| SCHEMBL6687346 | 0.78 | PTPN1 (0.66) | PTPN1PTPN2 | |
| SCHEMBL6687344 | 0.77 | PTPN1 (0.65) | PTPN1PTPN2 | |
| SCHEMBL6688145 | 0.76 | PTPN1 (0.63) | PTPN1PTPN2 | |
| SCHEMBL2937374 | 0.72 | PTPN1 (0.52) | PTPN1GRM5PTPN2 | |
| SCHEMBL1732384 | 0.72 | PTPN1 (0.64) | PTPN1PTPN2 | |
| SCHEMBL4643548 | 0.71 | PTPN1 (0.45) | PTPN1 | |
| SCHEMBL31285190 | 0.68 | PTPN1 (0.41) | PTPN1PTPN2GRM4 | |
| SCHEMBL3929924 | 0.68 | PTPN1 (0.45) | PTPN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004041799-A1 | 5- (SUBSTITUTED PHENYL) -THIADIAZOLIDINE-3-ONES AND THEIR USE AS PTP1B | ASTRAZENECA AB (SE) | 2004-05-21 | — | — | WO | disclosed |