Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | HPGD | P15428 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.44 |
| ▸ | APP | P05067 | 2/20 | 0.43 |
| ▸ | NOS2 | P35228 | 1/20 | 0.43 |
| ▸ | NCF1 | P14598 | 1/20 | 0.43 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.43 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.43 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.43 |
| ▸ | DHFR | P00374 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | FABP1 | P07148 | 1/20 | 0.42 |
| ▸ | FABP6 | P51161 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6469221 | 0.75 | MEN1 (0.57) | EGFRSMN1; SMN2ALDH1A1HPGDMAP4K4 | |
| SCHEMBL7173404 | 0.73 | SMN1; SMN2 (0.54) | SMN1; SMN2ALDH1A1HPGDKDM4ENOS2 | |
| SCHEMBL12685852 | 0.73 | HDAC3 (0.49) | SMN1; SMN2ALDH1A1HPGDMAP4K4NOS2 | |
| SCHEMBL23609251 | 0.71 | CYP1A2 (0.49) | SMN1; SMN2ALDH1A1HPGDNOS2MEN1 | |
| SCHEMBL10005387 | 0.70 | CYP2D6 (0.56) | EGFRSMN1; SMN2ALDH1A1HPGDKDM4E | |
| SCHEMBL27981294 | 0.68 | HDAC1 (0.56) | EGFR | |
| SCHEMBL7231916 | 0.68 | FABP1 (0.58) | EGFRSMN1; SMN2ALDH1A1HPGDKDM4E | |
| SCHEMBL13101047 | 0.67 | FYN (0.59) | SMN1; SMN2ALDH1A1HPGDMAP4K4APP | |
| SCHEMBL7459147 | 0.67 | NOS2 (0.66) | EGFRSMN1; SMN2ALDH1A1HPGDKDM4E | |
| SCHEMBL13256483 | 0.67 | FABP1 (0.51) | SMN1; SMN2ALDH1A1HPGDKDM4EMAP4K4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004082613-A2 | 2,4-DIAMINO-5-[5’-SUBSTITUTED-BENZYL] PYRIMIDINES AND 2,4-DIAMINO-6-[5’-SUBSTITUTED-BENZYL] QUINAZOLINES | DANA FARBER CANCER INSTITUTE (US) | 2004-09-30 | — | — | WO | disclosed |