Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.57 |
| ▸ | HPGD | P15428 | 1/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.57 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.53 |
| ▸ | NCOR1 | O75376 | 2/20 | 0.53 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.53 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.53 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.53 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.53 |
| ▸ | FABP1 | P07148 | 1/20 | 0.53 |
| ▸ | FABP6 | P51161 | 1/20 | 0.53 |
| ▸ | EGFR | P00533 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | BACE1 | P56817 | 1/20 | 0.47 |
| ▸ | TPH1 | P17752 | 1/20 | 0.47 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.47 |
| ▸ | NOS2 | P35228 | 1/20 | 0.46 |
| ▸ | APP | P05067 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5040443 | 0.83 | L3MBTL1 (0.50) | ALDH1A1HDAC3HDAC1HDAC2HDAC6 | |
| SCHEMBL22191398 | 0.79 | ALDH1A1 (0.57) | MEN1ALDH1A1HPGDKMT2AHDAC3 | |
| SCHEMBL7231916 | 0.79 | FABP1 (0.58) | MEN1ALDH1A1HPGDKMT2AHDAC3 | |
| SCHEMBL6469219 | 0.76 | HDAC3 (0.64) | MEN1ALDH1A1HPGDKMT2AHDAC3 | |
| SCHEMBL11060936 | 0.75 | HTT (0.55) | MEN1ALDH1A1KMT2AHDAC1EGFR | |
| SCHEMBL6685508 | 0.75 | EGFR (0.46) | MEN1ALDH1A1HPGDKMT2AFABP1 | |
| SCHEMBL507498 | 0.74 | FABP1 (0.56) | MEN1ALDH1A1HPGDKMT2AHDAC1 | |
| SCHEMBL5134065 | 0.74 | MEN1 (0.53) | MEN1KMT2AEGFRPOLBBACE1 | |
| SCHEMBL10005387 | 0.74 | CYP2D6 (0.56) | MEN1ALDH1A1HPGDKMT2AFABP1 | |
| SCHEMBL13101047 | 0.74 | FYN (0.59) | MEN1ALDH1A1HPGDKMT2AFABP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050107381-A1 | 6-membered heteroaryl compounds for the treatment of neurodegenerative disorders | PFIZER, INC. | 2005-05-19 | — | — | US | claimed |
| US-20050107381-A1 | 6-membered heteroaryl compounds for the treatment of neurodegenerative disorders | PFIZER, INC. | 2005-05-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050107381-A1 | 6-membered heteroaryl compounds for the treatment of neurodegenerative disorders | APP, BACE1, SNCA | MEN1 978/4885ALDH1A1 2820/4885HPGD 3060/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.