Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 8/20 | 0.55 |
| ▸ | RAB9A | P51151 | 8/20 | 0.55 |
| ▸ | JAK2 | O60674 | 4/20 | 0.55 |
| ▸ | JAK1 | P23458 | 3/20 | 0.55 |
| ▸ | MAOB | P27338 | 1/20 | 0.53 |
| ▸ | POLB | P06746 | 1/20 | 0.53 |
| ▸ | TMIGD3 | P0DMS9 | 1/20 | 0.51 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.51 |
| ▸ | ROCK2 | O75116 | 4/20 | 0.49 |
| ▸ | ROCK1 | Q13464 | 4/20 | 0.49 |
| ▸ | CLK2 | P49760 | 3/20 | 0.49 |
| ▸ | DYRK1A | Q13627 | 3/20 | 0.49 |
| ▸ | CLK4 | Q9HAZ1 | 3/20 | 0.49 |
| ▸ | DYRK3 | O43781 | 2/20 | 0.49 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.49 |
| ▸ | RPS6KB1 | P23443 | 2/20 | 0.49 |
| ▸ | CLK1 | P49759 | 1/20 | 0.49 |
| ▸ | DYRK2 | Q92630 | 1/20 | 0.49 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.49 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2566770 | 0.79 | NPC1 (0.65) | NPC1RAB9AJAK2JAK1MAOB | |
| SCHEMBL12245667 | 0.73 | RAB9A (0.58) | NPC1RAB9AJAK2JAK1MAOB | |
| SCHEMBL25131975 | 0.73 | NPC1 (0.75) | NPC1RAB9AJAK2JAK1MAOB | |
| SCHEMBL4920219 | 0.72 | PLAU (0.46) | NPC1RAB9APOLB | |
| SCHEMBL15764656 | 0.72 | NPC1 (0.81) | NPC1RAB9AJAK2JAK1MAOB | |
| SCHEMBL15764662 | 0.72 | NPC1 (1.00) | NPC1RAB9AJAK2JAK1MAOB | |
| SCHEMBL15764657 | 0.72 | JAK2 (1.00) | NPC1RAB9AJAK2JAK1MAOB | |
| SCHEMBL4916251 | 0.72 | MAPT (0.44) | NPC1RAB9APOLBADORA1 | |
| SCHEMBL4922023 | 0.71 | MEN1 (0.46) | NPC1RAB9APOLBADORA1 | |
| SCHEMBL15764666 | 0.71 | NPC1 (0.81) | NPC1RAB9AJAK2JAK1MAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004037248-A2 | MODULATION OF PEROXISOME PROLIFERATOR ACTIVATED RECEPTORS ACTIVITY | CAREX SA (FR) | 2004-05-06 | — | — | WO | disclosed |