Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 17/20 | 0.62 |
| ▸ | FLT3 | P36888 | 9/20 | 0.62 |
| ▸ | KIT | P10721 | 8/20 | 0.62 |
| ▸ | CLK4 | Q9HAZ1 | 6/20 | 0.62 |
| ▸ | RET | P07949 | 6/20 | 0.62 |
| ▸ | FGFR1 | P11362 | 6/20 | 0.62 |
| ▸ | FLT1 | P17948 | 6/20 | 0.62 |
| ▸ | CSF1R | P07333 | 5/20 | 0.62 |
| ▸ | MAP4K4 | O95819 | 5/20 | 0.62 |
| ▸ | MAP4K2 | Q12851 | 5/20 | 0.62 |
| ▸ | ROCK1 | Q13464 | 5/20 | 0.62 |
| ▸ | NTRK2 | Q16620 | 5/20 | 0.62 |
| ▸ | AXL | P30530 | 5/20 | 0.62 |
| ▸ | HIPK4 | Q8NE63 | 5/20 | 0.62 |
| ▸ | ABL1 | P00519 | 4/20 | 0.62 |
| ▸ | NTRK1 | P04629 | 4/20 | 0.62 |
| ▸ | LCK | P06239 | 4/20 | 0.62 |
| ▸ | CLK2 | P49760 | 4/20 | 0.62 |
| ▸ | RPS6KA3 | P51812 | 4/20 | 0.62 |
| ▸ | DYRK1A | Q13627 | 4/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7070852 | 0.91 | KDR (0.55) | KDRFLT3KITCLK4RET | |
| SCHEMBL7067102 | 0.89 | KDR (0.52) | KDRFLT3KITCLK4RET | |
| SCHEMBL7069565 | 0.87 | KDR (0.64) | KDRFLT3KITCLK4RET | |
| SCHEMBL7070857 | 0.87 | KDR (0.66) | KDRFLT3KITCLK4RET | |
| SCHEMBL3604170 | 0.77 | KDR (0.67) | KDRFLT3KITRETFGFR1 | |
| SCHEMBL3617885 | 0.77 | KDR (0.46) | KDRFLT3KITCLK4RET | |
| SCHEMBL7071304 | 0.77 | KDR (0.54) | KDRFLT3KITCLK4RET | |
| SCHEMBL232042 | 0.77 | KDR (1.00) | KDRFLT3KITCLK4RET | |
| SCHEMBL3122034 | 0.76 | KDR (0.62) | KDRFLT3KITCLK4RET | |
| SCHEMBL7070865 | 0.76 | KDR (0.52) | KDRFLT3KITCLK4RET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1487841-A1 | THIOPYRIMIDINE AND ISOTHIAZOLOPYRIMIDINE KINASE INHIBITORS | Abbott Laboratories (US) | 2004-12-22 | — | — | EP | disclosed |
| WO-2003080625-A1 | THIOPYRIMIDINE AND ISOTHIAZOLOPYRIMIDINE KINASE INHIBITORS | ABBOTT LABORATORIES (US) | 2003-10-02 | — | — | WO | disclosed |