Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 16/20 | 0.64 |
| ▸ | FLT3 | P36888 | 10/20 | 0.64 |
| ▸ | KIT | P10721 | 9/20 | 0.64 |
| ▸ | MAP4K4 | O95819 | 7/20 | 0.50 |
| ▸ | MAP4K2 | Q12851 | 7/20 | 0.50 |
| ▸ | LCK | P06239 | 7/20 | 0.50 |
| ▸ | ROCK1 | Q13464 | 6/20 | 0.50 |
| ▸ | NTRK2 | Q16620 | 6/20 | 0.50 |
| ▸ | CLK4 | Q9HAZ1 | 6/20 | 0.50 |
| ▸ | PLK4 | O00444 | 6/20 | 0.50 |
| ▸ | MARK3 | P27448 | 6/20 | 0.50 |
| ▸ | AXL | P30530 | 6/20 | 0.50 |
| ▸ | STK3 | Q13188 | 6/20 | 0.50 |
| ▸ | HIPK4 | Q8NE63 | 6/20 | 0.50 |
| ▸ | SLK | Q9H2G2 | 6/20 | 0.50 |
| ▸ | MKNK2 | Q9HBH9 | 6/20 | 0.50 |
| ▸ | RET | P07949 | 6/20 | 0.50 |
| ▸ | FGFR1 | P11362 | 6/20 | 0.50 |
| ▸ | FLT1 | P17948 | 6/20 | 0.50 |
| ▸ | CSF1R | P07333 | 6/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7072125 | 0.88 | KDR (0.56) | KDRFLT3KITMAP4K4MAP4K2 | |
| SCHEMBL7070857 | 0.88 | KDR (0.66) | KDRFLT3KITMAP4K4MAP4K2 | |
| SCHEMBL6686233 | 0.87 | KDR (0.62) | KDRFLT3KITMAP4K4MAP4K2 | |
| SCHEMBL6647235 | 0.87 | KDR (0.51) | KDRFLT3KITMAP4K4MAP4K2 | |
| SCHEMBL6090597 | 0.79 | KIT (0.52) | KDRFLT3KITMAP4K4MAP4K2 | |
| SCHEMBL7071304 | 0.79 | KDR (0.54) | KDRFLT3KITMAP4K4MAP4K2 | |
| SCHEMBL7070852 | 0.78 | KDR (0.55) | KDRFLT3KITMAP4K4MAP4K2 | |
| SCHEMBL4481371 | 0.78 | KDR (1.00) | KDRFLT3KITMAP4K4MAP4K2 | |
| SCHEMBL7067102 | 0.77 | KDR (0.52) | KDRFLT3KITMAP4K4MAP4K2 | |
| SCHEMBL3609309 | 0.74 | KDR (0.56) | KDRFLT3KITMAP4K4MAP4K2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20030225273-A1 | Thiopyrimidine and isothiazolopyrimidine kinase inhibitors | ABBOTT LABORATORIES | 2003-12-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030225273-A1 | Thiopyrimidine and isothiazolopyrimidine kinase inhibitors | ABL1, ERBB2, LCK | KDR 425/4885FLT3 29/4885KIT 394/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.