Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 11/20 | 0.52 |
| ▸ | FGFR1 | P11362 | 10/20 | 0.52 |
| ▸ | RET | P07949 | 6/20 | 0.52 |
| ▸ | FLT1 | P17948 | 6/20 | 0.52 |
| ▸ | LCK | P06239 | 6/20 | 0.52 |
| ▸ | MAP4K4 | O95819 | 5/20 | 0.52 |
| ▸ | ABL1 | P00519 | 5/20 | 0.52 |
| ▸ | NTRK1 | P04629 | 5/20 | 0.52 |
| ▸ | CSF1R | P07333 | 5/20 | 0.52 |
| ▸ | CLK2 | P49760 | 5/20 | 0.52 |
| ▸ | RPS6KA3 | P51812 | 5/20 | 0.52 |
| ▸ | MAP4K2 | Q12851 | 5/20 | 0.52 |
| ▸ | ROCK1 | Q13464 | 5/20 | 0.52 |
| ▸ | DYRK1A | Q13627 | 5/20 | 0.52 |
| ▸ | NTRK2 | Q16620 | 5/20 | 0.52 |
| ▸ | TAOK1 | Q7L7X3 | 5/20 | 0.52 |
| ▸ | CLK4 | Q9HAZ1 | 5/20 | 0.52 |
| ▸ | MET | P08581 | 4/20 | 0.52 |
| ▸ | NTRK3 | Q16288 | 4/20 | 0.52 |
| ▸ | GSK3B | P49841 | 4/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6686233 | 0.89 | KDR (0.62) | KDRFGFR1RETFLT1LCK | |
| SCHEMBL7070852 | 0.83 | KDR (0.55) | KDRFGFR1RETFLT1LCK | |
| SCHEMBL7071304 | 0.78 | KDR (0.54) | KDRFGFR1RETFLT1LCK | |
| SCHEMBL7069565 | 0.77 | KDR (0.64) | KDRFGFR1RETFLT1LCK | |
| SCHEMBL4474877 | 0.76 | KDR (0.80) | KDRFGFR1RETFLT1LCK | |
| SCHEMBL7070857 | 0.76 | KDR (0.66) | KDRFGFR1RETFLT1LCK | |
| SCHEMBL6647235 | 0.75 | KDR (0.51) | KDRFGFR1RETFLT1LCK | |
| SCHEMBL29923744 | 0.75 | FLT1 (0.62) | KDRFGFR1RETFLT1LCK | |
| SCHEMBL20816501 | 0.75 | FLT1 (0.62) | KDRFGFR1RETFLT1LCK | |
| SCHEMBL6646551 | 0.75 | KIT (0.53) | KDRFGFR1RETFLT1LCK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20030225273-A1 | Thiopyrimidine and isothiazolopyrimidine kinase inhibitors | ABBOTT LABORATORIES | 2003-12-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030225273-A1 | Thiopyrimidine and isothiazolopyrimidine kinase inhibitors | ABL1, ERBB2, LCK | KDR 425/4885FGFR1 193/4885RET 72/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.