Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | RECQL | P46063 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 10/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.41 |
| ▸ | CA1 | P00915 | 3/20 | 0.40 |
| ▸ | CA2 | P00918 | 3/20 | 0.40 |
| ▸ | MMP1 | P03956 | 1/20 | 0.40 |
| ▸ | MMP2 | P08253 | 1/20 | 0.40 |
| ▸ | MMP9 | P14780 | 1/20 | 0.40 |
| ▸ | MMP8 | P22894 | 1/20 | 0.40 |
| ▸ | MMP13 | P45452 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | CA9 | Q16790 | 2/20 | 0.39 |
| ▸ | CA12 | O43570 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31555979 | 0.89 | GAA (0.48) | SMN1; SMN2GAAALDH1A1MAPTADAM17 | |
| SCHEMBL20595268 | 0.85 | ALDH1A1 (0.47) | SMN1; SMN2GAAALDH1A1CA1CA2 | |
| SCHEMBL20595296 | 0.85 | ALDH1A1 (0.47) | SMN1; SMN2GAAALDH1A1CA1CA2 | |
| SCHEMBL8122003 | 0.84 | GAA (0.43) | SMN1; SMN2GAAALDH1A1CA1CA2 | |
| SCHEMBL10744933 | 0.84 | ALDH1A1 (0.46) | SMN1; SMN2RECQLGAAALDH1A1CA1 | |
| SCHEMBL1258986 | 0.81 | STAT3 (0.47) | SMN1; SMN2RECQLGAAALDH1A1MAPT | |
| SCHEMBL11692308 | 0.81 | CA2 (0.45) | SMN1; SMN2RECQLGAAALDH1A1CA1 | |
| SCHEMBL11599853 | 0.79 | GAA (0.46) | SMN1; SMN2RECQLGAAALDH1A1CA1 | |
| SCHEMBL10926820 | 0.79 | CA2 (0.41) | GAAALDH1A1CA1CA2CYP3A4 | |
| Methoxymethane SCHEMBL14118045 | 0.79 | STAT3 (0.44) | SMN1; SMN2RECQLGAAALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6774180-B2 | FOR CONJUGATION WITH BIOLOGICALLY ACTIVE AGENT IS SELECTED FROM A PROTEIN, PEPTIDE, CARBOHYDRATE, OLIGONUCLEOTIDE, DNA, RNA, AND LIPID | NEKTAR THERAPEUTICS AL, CORPORATION | 2004-08-10 | — | — | US | claimed |
| EP-1345982-A2 | SYNTHESIS OF HIGH MOLECULAR WEIGHT NON-PEPTIDIC POLYMER DERIVATIVES | Nektar Therapeutics Al, Corporation (US) | 2003-09-24 | — | — | EP | claimed |
| WO-2002059179-A2 | SYNTHESIS OF HIGH MOLECULAR WEIGHT NON-PEPTIDIC POLYMER DERIVATIVES | SHEARWATER CORPORATION (US) | 2002-08-01 | — | — | WO | claimed |
| US-20020082345-A1 | Synthesis of high molecular weight non-peptidic polymer derivatives | SHEARWATER CORPORATION | 2002-06-27 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020082345-A1 | Synthesis of high molecular weight non-peptidic polymer derivatives | ACP1, MRPS27, EPS15 | SMN1; SMN2 4457/4885RECQL 4503/4885GAA 626/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.