Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 8/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.52 |
| ▸ | MEN1 | O00255 | 2/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.52 |
| ▸ | TNKS | O95271 | 1/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.52 |
| ▸ | GPR3 | P46089 | 1/20 | 0.52 |
| ▸ | BLM | P54132 | 1/20 | 0.52 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.52 |
| ▸ | PARP15 | Q460N3 | 1/20 | 0.52 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.52 |
| ▸ | GRM6 | O15303 | 1/20 | 0.49 |
| ▸ | GLA | P06280 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | THRB | P10828 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6685739 | 0.85 | PARP1 (0.55) | PARP1KDM4EKMT2AMEN1ALDH1A1 | |
| SCHEMBL7714636 | 0.84 | IMPDH2 (0.56) | PARP1KDM4EKMT2AMEN1ALDH1A1 | |
| SCHEMBL20227727 | 0.77 | PARP1 (0.58) | PARP1KDM4EKMT2AMEN1ALDH1A1 | |
| SCHEMBL20597354 | 0.77 | IMPDH2 (0.67) | PARP1KDM4EKMT2AMEN1ALDH1A1 | |
| SCHEMBL16530066 | 0.76 | CA9 (0.44) | PARP1KDM4EKMT2AMEN1ALDH1A1 | |
| SCHEMBL8926269 | 0.73 | PARP1 (0.60) | PARP1KDM4EKMT2AMEN1ALDH1A1 | |
| SCHEMBL11582792 | 0.72 | PARP1 (0.57) | PARP1KDM4EKMT2AMEN1ALDH1A1 | |
| SCHEMBL2026877 | 0.72 | CA1 (0.52) | KDM4EKMT2AMEN1ALDH1A1HSD17B10 | |
| SCHEMBL23132415 | 0.72 | PARP1 (0.64) | PARP1KDM4EKMT2AMEN1ALDH1A1 | |
| SCHEMBL9747625 | 0.71 | KMT2A (0.56) | PARP1KDM4EKMT2AMEN1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6723733-B2 | POLYMERASE INHIBITOR | GUILFORD PHARMACEUTICALS, INC. | 2004-04-20 | — | — | US | disclosed |
| US-20020006927-A1 | Sulfonamide and carbamide derivatives of 6(5H)phenanthridinones and their uses | EISAI INC. | 2002-01-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020006927-A1 | Sulfonamide and carbamide derivatives of 6(5H)phenanthridinones and their uses | PARP1, PARP2, PARP6 | PARP1 1/4885KDM4E 231/4885KMT2A 260/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.