Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Citric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA4 | P22748 | 5/20 | 0.94 |
| ▸ | FAHD1 | Q6P587 | 1/20 | 0.37 |
| ▸ | CASP1 | P29466 | 1/20 | 0.36 |
| ▸ | FFAR3 | O14843 | 1/20 | 0.32 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.32 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.32 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.32 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | LDHA | P00338 | 1/20 | 0.32 |
| ▸ | BLM | P54132 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | CA2 | P00918 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Citric Acid SCHEMBL6690080 | 1.00 | CA4 (0.94) | CA4FAHD1CASP1FFAR3HDAC3 | |
| Citric Acid SCHEMBL989893 | 1.00 | CA4 (0.94) | CA4FAHD1CASP1FFAR3HDAC3 | |
| Citric Acid SCHEMBL1303277 | 0.97 | CA4 (0.90) | CA4FAHD1CASP1FFAR3HDAC3 | |
| Citric Acid SCHEMBL8761101 | 0.97 | CA4 (0.90) | CA4FAHD1CASP1FFAR3HDAC3 | |
| Citric Acid SCHEMBL5328814 | 0.97 | CA4 (0.90) | CA4FAHD1CASP1FFAR3HDAC3 | |
| Citric Acid SCHEMBL23672268 | 0.97 | CA4 (0.90) | CA4FAHD1CASP1FFAR3HDAC3 | |
| Citric Acid SCHEMBL4818290 | 0.97 | CA4 (0.90) | CA4FAHD1CASP1FFAR3HDAC3 | |
| Citric Acid SCHEMBL5617378 | 0.97 | CA4 (0.90) | CA4FAHD1CASP1FFAR3HDAC3 | |
| Citric Acid SCHEMBL5617376 | 0.97 | CA4 (0.90) | CA4FAHD1CASP1FFAR3HDAC3 | |
| Citric Acid SCHEMBL1650869 | 0.97 | CA4 (0.90) | CA4FAHD1CASP1FFAR3HDAC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109072134-B | Formulations, their preparation and use and suitable components | 巴斯夫欧洲公司 | 2021-05-07 | — | — | CN | disclosed |
| US-10844323-B2 | Formulations, the production and use thereof, and suitable components | BASF SE (DE) | 2020-11-24 | — | — | US | disclosed |
| EP-3448975-B1 | FORMULATIONS, THEIR PREPARATION AND USE, AND SUITABLE COMPOUNDS | BASF SE (DE) | 2020-04-01 | — | — | EP | disclosed |
| US-20190136152-A1 | FORMULATIONS, THE PRODUCTION AND USE THEREOF, AND SUITABLE COMPONENTS | BASF SE (DE) | 2019-05-09 | — | — | US | disclosed |
| WO-2004101147-A1 | REGENERATION METHOD FOR CATION EXCHANGERS | WP ENGINEERING LIMITED (MT) | 2004-11-25 | — | — | WO | disclosed |
| US-4128691-A | ELECTROLESS PLATING | FUJI PHOTO FILM CO., LTD. (JP) | 1978-12-05 | — | — | US | disclosed |
| US-4027069-A | VISCOSITY DEGRADATION STABILIZED, POLYVINYL ACETAL | MONSANTO COMPANY (US) | 1977-05-31 | — | — | US | disclosed |
| US-4017444-A | SAFETY GLASS | MONSANTO COMPANY (US) | 1977-04-12 | — | — | US | disclosed |