Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Citric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA4 | P22748 | 5/20 | 0.94 |
| ▸ | FAHD1 | Q6P587 | 1/20 | 0.37 |
| ▸ | CASP1 | P29466 | 1/20 | 0.36 |
| ▸ | FFAR3 | O14843 | 1/20 | 0.32 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.32 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.32 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.32 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | LDHA | P00338 | 1/20 | 0.32 |
| ▸ | BLM | P54132 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | CA2 | P00918 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Citric Acid SCHEMBL6690080 | 1.00 | CA4 (0.94) | CA4FAHD1CASP1FFAR3HDAC3 | |
| Citric Acid SCHEMBL6687136 | 1.00 | CA4 (0.94) | CA4FAHD1CASP1FFAR3HDAC3 | |
| Citric Acid SCHEMBL1303277 | 0.97 | CA4 (0.90) | CA4FAHD1CASP1FFAR3HDAC3 | |
| Citric Acid SCHEMBL8761101 | 0.97 | CA4 (0.90) | CA4FAHD1CASP1FFAR3HDAC3 | |
| Citric Acid SCHEMBL5328814 | 0.97 | CA4 (0.90) | CA4FAHD1CASP1FFAR3HDAC3 | |
| Citric Acid SCHEMBL23672268 | 0.97 | CA4 (0.90) | CA4FAHD1CASP1FFAR3HDAC3 | |
| Citric Acid SCHEMBL4818290 | 0.97 | CA4 (0.90) | CA4FAHD1CASP1FFAR3HDAC3 | |
| Citric Acid SCHEMBL5617378 | 0.97 | CA4 (0.90) | CA4FAHD1CASP1FFAR3HDAC3 | |
| Citric Acid SCHEMBL5617376 | 0.97 | CA4 (0.90) | CA4FAHD1CASP1FFAR3HDAC3 | |
| Citric Acid SCHEMBL1650869 | 0.97 | CA4 (0.90) | CA4FAHD1CASP1FFAR3HDAC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 165 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-119708547-A | Metal-coated organic silicon resin microsphere and preparation method and application thereof | 江苏涌新材料科技有限公司 | 2025-03-28 | — | — | CN | claimed |
| CN-119529328-A | Metal-coated organosilicon elastomer microsphere, and preparation method and application thereof | 江苏涌新材料科技有限公司 | 2025-02-28 | — | — | CN | claimed |
| US-20250000865-A1 | COMPOUND FOR REDUCING URIC ACID LEVELS | NEWSOARA BIOPHARMA CO., LTD. (CN) | 2025-01-02 | — | — | US | claimed |
| CN-118268550-A | Method for preparing high sphericity nano nickel powder | 元颉新材料科技(浙江)有限公司 | 2024-07-02 | — | — | CN | claimed |
| CN-118079003-A | Phosphodiesterase type 5 inhibitors for lowering uric acid levels and uses thereof | 海南大学 | 2024-05-28 | — | — | CN | claimed |
| CN-114530598-B | Nitrogen-oxygen-sulfur doped carbon negative electrode material and preparation method and application thereof | 广东工业大学 | 2024-05-07 | — | — | CN | claimed |
| CN-115448289-B | Oxygen-fluorine co-doped hard carbon anode material and preparation method and application thereof | 广东工业大学 | 2023-12-01 | — | — | CN | claimed |
| CN-111315155-B | Method for improving alignment degree of outer layer of mini LED PCB | 惠州中京电子科技有限公司 | 2023-07-04 | — | — | CN | claimed |
| US-20230201386-A1 | PRODUCING RADIOPHARMACEUTICAL COLD KITS WITHOUT LYOPHILIZATION | THE BOARD OF REGENTS OF THE UNIVERSITY OF OKLAHOMA | 2023-06-29 | — | — | US | claimed |
| CN-111957986-B | Spherical nano copper powder and preparation method and application thereof | 湖南泽宇新材料有限公司 | 2023-04-18 | — | — | CN | claimed |
| WO-2019192116-A1 | CHARGED COMPOSITE MEMBRANE HAVING ELECTRICAL TOPOLOGY CHARACTERISTICS OF EXTRACELLULAR MATRIX AND PREPARATION METHOD THEREFOR | 北京大学口腔医学院 | 2019-10-10 | — | — | WO | claimed |
| CN-108570692-A | A method of by the leaded converting waste material containing lead battery be metallic lead | 西安优庆商贸有限公司 | 2018-09-25 | — | — | CN | claimed |
| CN-104164443-B | A kind of Dual-Luciferase detecting live body yeast cells UPR level monitors plasmid and structure thereof and application | 东华大学 | 2016-11-16 | — | — | CN | claimed |
| CN-104164443-A | Dual-luciferase monitoring plasmid for detecting living yeast cell UPR level, construction and application thereof | NAT UNIV DONG HWA | 2014-11-26 | — | — | CN | claimed |
| CN-101831668-B | Clean wet-method solid-liquid two-phase electroreduction lead recovery method | UNIV BEIJING CHEMICAL | 2012-02-22 | — | — | CN | claimed |
| CN-101831668-A | Clean wet-method solid-liquid two-phase electroreduction lead recovery method | UNIV BEIJING CHEMICAL | 2010-09-15 | — | — | CN | claimed |
| US-20040007469-A1 | Forming three-dimensional multilayer structures by electroplating, ammonium citrate is included to improve anode dissolving, prevent deposits defect and short circuits, use low voltage; copper deposits has ductility, noncracking | MEMGEN CORPORATION | 2004-01-15 | — | — | US | claimed |
| US-5849268-A | Oral compositions | THE PROCTER & GAMBLE COMPANY (US) | 1998-12-15 | — | — | US | claimed |
| US-5620679-A | Oral compositions | THE PROCTER & GAMBLE COMPANY (US) | 1997-04-15 | — | — | US | claimed |
| WO-1995031174-A1 | ORAL COMPOSITIONS | THE PROCTER & GAMBLE COMPANY (US) | 1995-11-23 | — | — | WO | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20250000865-A1 | COMPOUND FOR REDUCING URIC ACID LEVELS | PDE4A, PDE4B, PDE12 | CA4 82/4885FAHD1 787/4885CASP1 930/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.