Citric Acid

Citric Acid

SCHEMBL1650869

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nearest known ligand 0.90

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

GSK3AGSK3BHRH2IMPA1

The experimentally established mechanism targets of Citric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
CA4 P22748 5/20 0.90
FAHD1 Q6P587 1/20 0.35
CASP1 P29466 1/20 0.35
FFAR3 O14843 1/20 0.31
HDAC3 O15379 1/20 0.31
HDAC1 Q13547 1/20 0.31
HDAC2 Q92769 1/20 0.31
HDAC8 Q9BY41 1/20 0.31
ALDH1A1 P00352 1/20 0.31
MEN1 O00255 1/20 0.30
LDHA P00338 1/20 0.30
BLM P54132 1/20 0.30
KMT2A Q03164 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Citric Acid SCHEMBL23672268 1.00 CA4 (0.90) CA4FAHD1CASP1FFAR3HDAC3
Citric Acid SCHEMBL28869337 0.97 CA4 (0.85) CA4FAHD1CASP1
Citric Acid SCHEMBL5163322 0.97 CA4 (0.94) CA4FAHD1CASP1FFAR3HDAC3
Citric Acid SCHEMBL6690080 0.97 CA4 (0.94) CA4FAHD1CASP1FFAR3HDAC3
Citric Acid SCHEMBL8440714 0.97 CA4 (0.94) CA4FAHD1CASP1FFAR3HDAC3
Citric Acid SCHEMBL25212993 0.97 CA4 (0.94) CA4FAHD1CASP1FFAR3HDAC3
Citric Acid SCHEMBL372318 0.97 CA4 (0.84) CA4FAHD1CASP1ALDH1A1
Citric Acid SCHEMBL5311584 0.97 CA4 (0.84) CA4FAHD1CASP1ALDH1A1
Citric Acid SCHEMBL20917176 0.97 CA4 (0.94) CA4FAHD1CASP1FFAR3HDAC3
Citric Acid SCHEMBL260176 0.97 CA4 (0.94) CA4FAHD1CASP1FFAR3HDAC3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-109770164-A Dry agent is made in fructus lycii dewaxing 北方民族大学 2019-05-21 CN claimed
US-7588790-B2 Process for the removal of undesired flavour and odour components from potassium lactate PURAC BIOCHEM B.V. (NL) 2009-09-15 US claimed
US-4141841-A Antistatic, fabric-softening detergent additive THE PROCTER & GAMBLE COMPANY (US) 1979-02-27 US claimed
CN-118530973-A Stabilized cellulase variants 诺维信公司 2024-08-23 CN disclosed
CN-118460512-A Stabilized cellulase variants 诺维信公司 2024-08-09 CN disclosed
CN-112272701-B Stabilized cellulase variants 诺维信公司 2024-05-14 CN disclosed
CN-112204137-B Stabilized cellulase variants 诺维信公司 2024-05-14 CN disclosed
EP-3092072-B1 A PROCESS FOR VAPOR-PHASE METHANOL CARBONYLATION TO METHYL FORMATE FUJIAN INST RES STR MATTER CAS (CN) 2022-03-02 EP disclosed
EP-3827002-A1 TLR7/8 AGONISTS AND LIPOSOME COMPOSITIONS Torque Therapeutics, Inc. (US) 2021-06-02 EP disclosed
WO-2020023680-A1 TLR7/8 AGONISTS AND LIPOSOME COMPOSITIONS TORQUE THERAPEUTICS, INC. (US) 2020-01-30 WO disclosed
US-7927613-B2 Pharmaceutical co-crystal compositions UNIVERSITY OF SOUTH FLORIDA (US) 2011-04-19 US disclosed
EP-0591277-A1 LIQUID NUTRITIONAL PRODUCT. ABBOTT LAB (US) 1994-04-13 EP disclosed
EP-0591267-A1 BLEND OF DIETARY FIBER FOR NUTRITIONAL PRODUCTS. ABBOTT LAB (US) 1994-04-13 EP disclosed
EP-0591277-A4 LIQUID NUTRITIONAL PRODUCT. ABBOTT LAB (US) 1994-02-02 EP disclosed
EP-0591267-A4 BLEND OF DIETARY FIBER FOR NUTRITIONAL PRODUCTS. ABBOTT LAB (US) 1993-10-26 EP disclosed
WO-1993000020-A1 BLEND OF DIETARY FIBER FOR NUTRITIONAL PRODUCTS ABBOTT LABORATORIES (US) 1993-01-07 WO disclosed
WO-1993000019-A1 LIQUID NUTRITIONAL PRODUCT ABBOTT LABORATORIES (US) 1993-01-07 WO disclosed
US-5149368-A Resorbable bioactive calcium phosphate cement CERAMEDICAL, INC. 1992-09-22 US disclosed