Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP12 | P39900 | 7/20 | 0.43 |
| ▸ | MMP13 | P45452 | 6/20 | 0.43 |
| ▸ | HTT | P42858 | 3/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6687741 | 0.87 | MMP12 (0.40) | MMP12MMP13HTTCYP1A2CYP2C19 | |
| SCHEMBL5934949 | 0.81 | MMP12 (0.44) | MMP12MMP13HTTCYP1A2CYP2C19 | |
| SCHEMBL6681062 | 0.79 | MMP12 (0.43) | MMP12MMP13HTTCYP1A2CYP2C19 | |
| SCHEMBL7380975 | 0.79 | MMP12 (0.44) | MMP12MMP13HTTCYP1A2CYP2C19 | |
| SCHEMBL6687739 | 0.77 | MMP12 (0.42) | MMP12MMP13HTTCYP1A2CYP2C19 | |
| SCHEMBL6683187 | 0.76 | MMP12 (0.40) | MMP12MMP13 | |
| SCHEMBL5934913 | 0.75 | MMP12 (0.47) | MMP12MMP13HTTCYP1A2CYP2C19 | |
| SCHEMBL6681323 | 0.74 | HTT (0.41) | MMP12MMP13HTTCYP1A2CYP2C19 | |
| SCHEMBL7374325 | 0.73 | MMP12 (0.47) | MMP12MMP13HTTCYP1A2CYP2C19 | |
| SCHEMBL6685713 | 0.70 | MMP12 (0.43) | MMP12MMP13 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004058238-A1 | USE OF CATHEPSIN K INHIBITORS FOR THE TREATMENT OF GLAUCOMA | ALCON, INC. (CH) | 2004-07-15 | — | — | WO | claimed |
| EP-0934291-A1 | PROTEASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 1999-08-11 | — | — | EP | claimed |
| EP-0934291-A4 | — | SMITHKLINE BEECHAM CORP (US) | 1999-08-11 | — | — | EP | claimed |
| WO-1997016433-A1 | PROTEASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 1997-05-09 | — | — | WO | claimed |
| EP-0934291-A1 | PROTEASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 1999-08-11 | — | — | EP | disclosed |
| EP-0934291-A4 | — | SMITHKLINE BEECHAM CORP (US) | 1999-08-11 | — | — | EP | disclosed |
| WO-1997016433-A1 | PROTEASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 1997-05-09 | — | — | WO | disclosed |