Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP12 | P39900 | 2/20 | 0.40 |
| ▸ | MMP13 | P45452 | 2/20 | 0.40 |
| ▸ | CTSK | P43235 | 9/20 | 0.40 |
| ▸ | CTSL | P07711 | 4/20 | 0.40 |
| ▸ | CTSS | P25774 | 4/20 | 0.40 |
| ▸ | CTSB | P07858 | 2/20 | 0.40 |
| ▸ | CASP1 | P29466 | 1/20 | 0.39 |
| ▸ | CA5A | P35218 | 1/20 | 0.39 |
| ▸ | CA1 | P00915 | 1/20 | 0.38 |
| ▸ | HRAS | P01112 | 5/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6685713 | 0.96 | MMP12 (0.43) | MMP12MMP13CTSKCTSLCTSS | |
| SCHEMBL5934949 | 0.91 | MMP12 (0.44) | MMP12MMP13CTSKCTSSCTSB | |
| SCHEMBL7163257 | 0.87 | CTSK (0.46) | MMP12MMP13CTSKCTSLCTSS | |
| SCHEMBL5934913 | 0.87 | MMP12 (0.47) | MMP12MMP13CTSK | |
| SCHEMBL6681062 | 0.85 | MMP12 (0.43) | MMP12MMP13 | |
| SCHEMBL6687739 | 0.83 | MMP12 (0.42) | MMP12MMP13CTSK | |
| SCHEMBL5934907 | 0.82 | CA5A (0.52) | CTSKCTSLCTSSCTSBCASP1 | |
| SCHEMBL7374325 | 0.80 | MMP12 (0.47) | MMP12MMP13 | |
| SCHEMBL8042541 | 0.79 | CASP1 (0.49) | CTSKCTSLCTSSCTSBCASP1 | |
| SCHEMBL5934909 | 0.79 | CASP1 (0.49) | MMP12MMP13CTSKCTSLCTSS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004058238-A1 | USE OF CATHEPSIN K INHIBITORS FOR THE TREATMENT OF GLAUCOMA | ALCON, INC. (CH) | 2004-07-15 | — | — | WO | claimed |
| WO-2004058238-A1 | USE OF CATHEPSIN K INHIBITORS FOR THE TREATMENT OF GLAUCOMA | ALCON, INC. (CH) | 2004-07-15 | — | — | WO | disclosed |