Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR183 | P32249 | 1/20 | 0.46 |
| ▸ | PLAU | P00749 | 1/20 | 0.42 |
| ▸ | AGXT | P21549 | 1/20 | 0.42 |
| ▸ | NOS2 | P35228 | 1/20 | 0.41 |
| ▸ | PIK3CA | P42336 | 7/20 | 0.40 |
| ▸ | AKT1 | P31749 | 6/20 | 0.40 |
| ▸ | MTOR | P42345 | 4/20 | 0.39 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | LGMN | Q99538 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | NOS3 | P29474 | 1/20 | 0.36 |
| ▸ | NOS1 | P29475 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27885766 | 0.84 | GPR183 (0.44) | GPR183PLAUAGXTNOS2PIK3CA | |
| SCHEMBL29866545 | 0.81 | GPR183 (0.43) | GPR183PLAUAGXTPIK3CAAKT1 | |
| SCHEMBL672007 | 0.81 | GPR183 (0.43) | GPR183PLAUAGXTPIK3CAAKT1 | |
| SCHEMBL1662765 | 0.81 | GPR183 (0.45) | GPR183PLAUAGXTPIK3CAAKT1 | |
| SCHEMBL12831239 | 0.81 | KDM4E (0.44) | GPR183PLAUAGXTPIK3CAAKT1 | |
| SCHEMBL23662602 | 0.81 | GPR183 (0.43) | GPR183PLAUAGXTPIK3CAAKT1 | |
| SCHEMBL3508314 | 0.79 | KDM4E (0.50) | GPR183PIK3CAKDM4ERAB9ASMN1; SMN2 | |
| SCHEMBL6629681 | 0.78 | GPR183 (0.44) | GPR183PLAUAGXTPIK3CAAKT1 | |
| SCHEMBL23662642 | 0.77 | GPR183 (0.43) | GPR183PLAUAGXTPIK3CAAKT1 | |
| SCHEMBL2187269 | 0.76 | SLC13A5 (0.49) | AGXTTAAR1KDM4ERAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1392644-A1 | CINNAMIDE DERIVATIVES AS KCNQ POTASSIUM CHANNEL MODULATORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2004-03-03 | — | — | EP | disclosed |
| WO-2002096858-A1 | CINNAMIDE DERIVATIVES AS KCNQ POTASSIUM CHANNEL MODULATORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2002-12-05 | — | — | WO | disclosed |