Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR183 | P32249 | 1/20 | 0.44 |
| ▸ | PIK3CA | P42336 | 5/20 | 0.40 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.40 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.40 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.40 |
| ▸ | PRKDC | P78527 | 1/20 | 0.40 |
| ▸ | AGXT | P21549 | 1/20 | 0.39 |
| ▸ | AKT1 | P31749 | 4/20 | 0.39 |
| ▸ | MTOR | P42345 | 3/20 | 0.39 |
| ▸ | ACLY | P53396 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | MAOA | P21397 | 1/20 | 0.38 |
| ▸ | MAOB | P27338 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23662602 | 0.81 | GPR183 (0.43) | GPR183PIK3CAAGXTAKT1MTOR | |
| SCHEMBL1662765 | 0.81 | GPR183 (0.45) | GPR183PIK3CAPIK3CBAGXTAKT1 | |
| SCHEMBL672007 | 0.81 | GPR183 (0.43) | GPR183PIK3CAAGXTAKT1MTOR | |
| SCHEMBL29866545 | 0.81 | GPR183 (0.43) | GPR183PIK3CAAGXTAKT1MTOR | |
| SCHEMBL12831239 | 0.81 | KDM4E (0.44) | GPR183PIK3CAAGXTAKT1MTOR | |
| SCHEMBL16540072 | 0.80 | ALDH1A1 (0.39) | GPR183PIK3CAPIK3CDPRKDCAKT1 | |
| SCHEMBL22657488 | 0.79 | AKR1C3 (0.42) | GPR183PIK3CAPIK3CDPIK3CBPIK3CG | |
| SCHEMBL3508314 | 0.79 | KDM4E (0.50) | GPR183PIK3CAPRKDCACLYKDM4E | |
| SCHEMBL6688959 | 0.78 | GPR183 (0.46) | GPR183PIK3CAAGXTAKT1MTOR | |
| SCHEMBL27885766 | 0.78 | GPR183 (0.44) | GPR183PIK3CAAGXTAKT1MTOR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1392644-A1 | CINNAMIDE DERIVATIVES AS KCNQ POTASSIUM CHANNEL MODULATORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2004-03-03 | — | — | EP | disclosed |
| WO-2002096858-A1 | CINNAMIDE DERIVATIVES AS KCNQ POTASSIUM CHANNEL MODULATORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2002-12-05 | — | — | WO | disclosed |