SCHEMBL668900

SCHEMBL668900

CC(=O)OC1=CCc2c(ccc3c4c(ccc23)=CC=C4)=C1

nearest known ligand 0.00

⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9938266 0.84 KDM4E (0.30)
SCHEMBL15526804 0.77
SCHEMBL670186 0.68 KDM4E (0.31)
SCHEMBL8535227 0.57 PIM1 (0.36)
SCHEMBL11052386 0.56 LMNA (0.31)
SCHEMBL3024917 0.54
SCHEMBL7193554 0.53 LMNA (0.32)
SCHEMBL8530508 0.53 GLA (0.35)
SCHEMBL31648648 0.52
SCHEMBL11902996 0.52 GLA (0.33)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4232025-A1 PHOSPHINE REAGENTS FOR AZINE FLUOROALKYLATION COLORADO STATE UNIVERSITY RESEARCH FOUNDATION (US) 2023-08-30 EP disclosed
WO-2022087129-A1 PHOSPHINE REAGENTS FOR AZINE FLUOROALKYLATION COLORADO STATE UNIVERSITY RESEARCH FOUNDATION (US) 2022-04-28 WO disclosed
EP-3856756-A1 HALOGENATED CHOLESTEROL ANALOGUES AND METHODS OF MAKING AND USING SAME The Regents Of The University Of Michigan (US) 2021-08-04 EP disclosed
EP-3852764-A1 STEROL ANALOGS AND USES THEREOF ModernaTX, Inc. (US) 2021-07-28 EP disclosed
WO-2020069267-A1 HALOGENATED CHOLESTEROL ANALOGUES AND METHODS OF MAKING AND USING SAME THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) 2020-04-02 WO disclosed
WO-2020061332-A1 STEROL ANALOGS AND USES THEREOF MODERNATX, INC. (US) 2020-03-26 WO disclosed
EP-2970122-A1 SHIP1 MODULATORS AND METHODS RELATED THERETO Aquinox Pharmaceuticals (Canada) Inc. (CA) 2016-01-20 EP disclosed
WO-2014158654-A1 SHIP1 MODULATORS AND METHODS RELATED THERETO AQUINOX PHARMACEUTICALS INC. (CA) 2014-10-02 WO disclosed
EP-2651916-A2 C-17-HETEROARYL STEROIDAL COMPOUNDS AS INHIBITORS OF CYP11B, CYP17, AND/OR CYP21 BioMarin Pharmaceutical Inc. (US) 2013-10-23 EP disclosed
WO-2012083112-A2 CYP11B, CYP17, AND/OR CYP21 INHIBITORS BIOMARIN PHARMACEUTICAL INC. (US) 2012-06-21 WO disclosed
WO-2012022880-A2 METHOD FOR SYNTHESIZING STEROIDS UNIVERSITE DE STRASBOURG (FR) 2012-02-23 WO disclosed