Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 15/20 | 0.42 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | JAK1 | P23458 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6636072 | 0.88 | USP30 (0.44) | GPR119USP30ALDH1A1NPC1MAPT | |
| SCHEMBL4914329 | 0.74 | ALDH1A1 (0.43) | GPR119USP30ALDH1A1NPC1MAPT | |
| SCHEMBL23929008 | 0.74 | GPR119 (0.48) | GPR119MAPTHTTJAK1 | |
| SCHEMBL6633803 | 0.72 | MEN1 (0.43) | GPR119 | |
| SCHEMBL6620240 | 0.72 | MEN1 (0.43) | GPR119 | |
| SCHEMBL31627464 | 0.72 | GPR119 (0.52) | GPR119 | |
| SCHEMBL14521993 | 0.72 | GPR119 (0.47) | GPR119USP30 | |
| SCHEMBL30443695 | 0.72 | GPR119 (0.50) | GPR119USP30ALDH1A1NPC1MAPT | |
| SCHEMBL3486530 | 0.72 | GPR119 (0.69) | GPR119ALDH1A1MAPT | |
| SCHEMBL22730356 | 0.69 | GPR119 (0.43) | GPR119 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1485167-A1 | 1,2-DIHYDROPYRAZOL-3-ONES AS CYTOKINE MEDIATORS | The Procter & Gamble Company (US) | 2004-12-15 | — | — | EP | disclosed |
| WO-2003080184-A1 | 1,2-DIHYDROPYRAZOL-3-ONES AS CYTOKINE MEDIATORS | THE PROCTER & GAMBLE COMPANY (US) | 2003-10-02 | — | — | WO | disclosed |