Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | MKNK1 | Q9BUB5 | 3/20 | 0.44 |
| ▸ | MKNK2 | Q9HBH9 | 3/20 | 0.44 |
| ▸ | SYK | P43405 | 1/20 | 0.43 |
| ▸ | SIRT3 | Q9NTG7 | 2/20 | 0.43 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.42 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30060692 | 0.85 | CTNNB1 (0.68) | SMN1; SMN2KDM4ECTNNB1ALDH1A1MAPK1 | |
| SCHEMBL1702138 | 0.85 | CTNNB1 (0.68) | SMN1; SMN2KDM4ECTNNB1ALDH1A1MAPK1 | |
| SCHEMBL6689466 | 0.81 | KDM4E (0.55) | SMN1; SMN2KDM4EALDH1A1TDP1LMNA | |
| SCHEMBL4789960 | 0.75 | CTNNB1 (0.56) | CTNNB1ALDH1A1MAPK1HSD17B10LMNA | |
| SCHEMBL16044420 | 0.74 | BRD4 (0.77) | SMN1; SMN2KDM4E | |
| SCHEMBL27891963 | 0.74 | ALDH1A1 (0.51) | SMN1; SMN2CTNNB1ALDH1A1MAPK1HSD17B10 | |
| SCHEMBL29139940 | 0.74 | KMT2A (0.64) | SMN1; SMN2KDM4EALDH1A1MAPK1HSD17B10 | |
| SCHEMBL4982342 | 0.74 | CSNK1A1 (0.46) | SMN1; SMN2CTNNB1LMNA | |
| SCHEMBL6237458 | 0.74 | MKNK1 (0.58) | TDP1LMNAMKNK1MKNK2SIRT3 | |
| SCHEMBL15501779 | 0.73 | ALDH1A1 (0.53) | SMN1; SMN2CTNNB1ALDH1A1MAPK1HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1453789-A2 | N,N'-SUBSTITUTED-1,3-DIAMINO-2-HYDROXYPROPANE DERIVATIVES | Elan Pharmaceuticals, Inc. (US) | 2004-09-08 | — | — | EP | claimed |
| WO-2003040096-A2 | N, N'-SUBSTITUTED-1,3-DIAMINO-2-HYDROXYPROPANE DERIVATIVES | ELAN PHARMACEUTICALS, INC. (US) | 2003-05-15 | — | — | WO | claimed |