Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.55 |
| ▸ | MKNK1 | Q9BUB5 | 2/20 | 0.47 |
| ▸ | MKNK2 | Q9HBH9 | 2/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.46 |
| ▸ | SIRT3 | Q9NTG7 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | SYK | P43405 | 2/20 | 0.43 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | F7 | P08709 | 1/20 | 0.41 |
| ▸ | F3 | P13726 | 1/20 | 0.41 |
| ▸ | SARM1 | Q6SZW1 | 1/20 | 0.41 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.41 |
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.41 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.41 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.41 |
| ▸ | SIRT4 | Q9Y6E7 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30163333 | 0.82 | LMNA (0.60) | KDM4ETDP1LMNANOTUMSMN1; SMN2 | |
| SCHEMBL6689475 | 0.81 | SMN1; SMN2 (0.51) | KDM4EMKNK1MKNK2TDP1SIRT3 | |
| SCHEMBL1702138 | 0.77 | CTNNB1 (0.68) | KDM4EMKNK1MKNK2TDP1SIRT3 | |
| SCHEMBL30060692 | 0.77 | CTNNB1 (0.68) | KDM4EMKNK1MKNK2TDP1SIRT3 | |
| SCHEMBL4789958 | 0.76 | CTNNB1 (0.47) | KDM4EMKNK1MKNK2LMNAALDH1A1 | |
| SCHEMBL4982331 | 0.74 | CSNK1A1 (0.46) | KDM4EMKNK2TDP1SIRT3SMN1; SMN2 | |
| SCHEMBL6237449 | 0.74 | MKNK1 (0.62) | KDM4EMKNK1MKNK2TDP1SIRT3 | |
| SCHEMBL1863405 | 0.73 | ALDH1A1 (0.49) | KDM4ELMNASMN1; SMN2ALDH1A1HTT | |
| SCHEMBL3697056 | 0.73 | PARP10 (0.53) | KDM4ELMNASMN1; SMN2ALDH1A1HTT | |
| SCHEMBL28206486 | 0.72 | RAB9A (0.57) | KDM4ETDP1SMN1; SMN2ALDH1A1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1453789-A2 | N,N'-SUBSTITUTED-1,3-DIAMINO-2-HYDROXYPROPANE DERIVATIVES | Elan Pharmaceuticals, Inc. (US) | 2004-09-08 | — | — | EP | claimed |
| WO-2003040096-A2 | N, N'-SUBSTITUTED-1,3-DIAMINO-2-HYDROXYPROPANE DERIVATIVES | ELAN PHARMACEUTICALS, INC. (US) | 2003-05-15 | — | — | WO | claimed |