Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP13 | P45452 | 8/20 | 0.46 |
| ▸ | MMP1 | P03956 | 5/20 | 0.46 |
| ▸ | MMP2 | P08253 | 4/20 | 0.43 |
| ▸ | MMP3 | P08254 | 2/20 | 0.43 |
| ▸ | MMP9 | P14780 | 2/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.42 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.38 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.36 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.35 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.35 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.35 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.35 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.35 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.35 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.35 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.35 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.35 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.35 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6690364 | 0.93 | MMP13 (0.50) | MMP13MMP1MMP2MMP3MMP9 | |
| SCHEMBL6691208 | 0.91 | MMP1 (0.53) | MMP13MMP1MMP2MMP3MMP9 | |
| SCHEMBL6689092 | 0.83 | MMP13 (0.67) | MMP13MMP1MMP2MMP3MMP9 | |
| SCHEMBL6690792 | 0.82 | MMP13 (0.66) | MMP13MMP1MMP2MMP3MMP9 | |
| SCHEMBL6693302 | 0.81 | MMP13 (0.55) | MMP13MMP1MMP2MMP3MMP9 | |
| SCHEMBL6697906 | 0.80 | MMP13 (0.69) | MMP13MMP1MMP2MMP3MMP9 | |
| SCHEMBL6697408 | 0.79 | MMP13 (0.67) | MMP13MMP1MMP2MMP3MMP9 | |
| SCHEMBL6691033 | 0.78 | MMP13 (0.70) | MMP13MMP1MMP2MMP3MMP9 | |
| SCHEMBL6691331 | 0.78 | MMP13 (0.67) | MMP13MMP1MMP2MMP3MMP9 | |
| SCHEMBL6693818 | 0.77 | MMP13 (0.71) | MMP13MMP1MMP2MMP3MMP9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1134215-B1 | 2-oxo-imidazolidine-4-carboxylic acid hydroxamine compounds that inhibit matrix metalloproteinases | PFIZER PROD INC (US) | 2004-10-06 | — | — | EP | claimed |