Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 4/20 | 1.00 |
| ▸ | HTR3A | P46098 | 5/20 | 0.68 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.59 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.58 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.55 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.54 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.54 |
| ▸ | MEN1 | O00255 | 1/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.54 |
| ▸ | POLB | P06746 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.53 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.53 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6686759 | 0.89 | PARP1 (1.00) | PARP1HTR3ACD274HSD17B10ALDH1A1 | |
| SCHEMBL2483444 | 0.83 | PARP1 (0.89) | PARP1HTR3AHSD17B10ALDH1A1MEN1 | |
| SCHEMBL10132619 | 0.82 | PARP1 (0.72) | PARP1HTR3AHSD17B10ALDH1A1TNKS2 | |
| SCHEMBL6690145 | 0.78 | PARP1 (0.65) | PARP1ALDH1A1KMT2APOLBCYP2D6 | |
| SCHEMBL2615238 | 0.78 | CD274 (0.92) | CD274EPHX2ALDH1A1POLBLMNA | |
| SCHEMBL2615239 | 0.78 | CD274 (0.92) | CD274EPHX2ALDH1A1POLBLMNA | |
| SCHEMBL29584690 | 0.76 | CYP2C19 (0.69) | PARP1CD274EPHX2ALDH1A1POLB | |
| SCHEMBL3344406 | 0.74 | PARP1 (0.83) | PARP1HTR3ACD274HSD17B10ALDH1A1 | |
| SCHEMBL13943783 | 0.73 | HTR3A (0.81) | PARP1HTR3AHSD17B10CACNA1GALDH1A1 | |
| Hydrochloric Acid SCHEMBL11864237 | 0.73 | PARP1 (0.58) | PARP1ALDH1A1MEN1KMT2ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6723733-B2 | POLYMERASE INHIBITOR | GUILFORD PHARMACEUTICALS, INC. | 2004-04-20 | — | — | US | disclosed |
| US-20020006927-A1 | Sulfonamide and carbamide derivatives of 6(5H)phenanthridinones and their uses | EISAI INC. | 2002-01-17 | — | — | US | disclosed |
| WO-2001090077-A1 | SULFONAMIDE AND CARBAMIDE DERIVATIVES OF 6(5H)PHENANTHRIDINONES AND THEIR USES | GUILFORD PHARMACEUTICALS, INC. (US) | 2001-11-29 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020006927-A1 | Sulfonamide and carbamide derivatives of 6(5H)phenanthridinones and their uses | PARP1, PARP2, PARP6 | PARP1 1/4885HTR3A 444/4885CD274 1913/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.