Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 8/20 | 0.65 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.49 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.49 |
| ▸ | PKM | P14618 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6685976 | 0.81 | PARP1 (0.81) | PARP1ALDH1A1MAPK1PKMPOLB | |
| SCHEMBL6689801 | 0.78 | PARP1 (1.00) | PARP1ALDH1A1CYP2D6CYP2C19KMT2A | |
| SCHEMBL5605356 | 0.73 | ALDH1A1 (0.69) | ALDH1A1MAPK1CYP3A4CYP2D6CYP2C19 | |
| SCHEMBL1410741 | 0.71 | SIGMAR1 (0.76) | ALDH1A1MAPK1PKMKMT2APOLB | |
| SCHEMBL6015810 | 0.71 | ALDH1A1 (0.60) | ALDH1A1MAPK1CYP3A4CYP2D6CYP2C19 | |
| SCHEMBL6690931 | 0.70 | PARP1 (0.64) | PARP1ALDH1A1CYP2C19PKMKMT2A | |
| SCHEMBL6694764 | 0.70 | PARP1 (1.00) | PARP1MAPK1 | |
| SCHEMBL25011236 | 0.70 | MAPK1 (0.55) | ALDH1A1MAPK1CYP3A4CYP2D6CYP2C19 | |
| SCHEMBL2763527 | 0.70 | PARP1 (0.90) | PARP1ALDH1A1MAPK1POLB | |
| SCHEMBL4619595 | 0.69 | ALDH1A1 (0.67) | ALDH1A1MAPK1CYP3A4CYP2D6CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6723733-B2 | POLYMERASE INHIBITOR | GUILFORD PHARMACEUTICALS, INC. | 2004-04-20 | — | — | US | disclosed |
| US-20020006927-A1 | Sulfonamide and carbamide derivatives of 6(5H)phenanthridinones and their uses | EISAI INC. | 2002-01-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020006927-A1 | Sulfonamide and carbamide derivatives of 6(5H)phenanthridinones and their uses | PARP1, PARP2, PARP6 | PARP1 1/4885ALDH1A1 1532/4885MAPK1 4036/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.