Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 6/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.50 |
| ▸ | TYMS | P04818 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.42 |
| ▸ | MEN1 | O00255 | 3/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.42 |
| ▸ | PSMD14 | O00487 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.40 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4480638 | 0.85 | HPGD (0.66) | HPGDALDH1A1CYP3A4TYMSMAPK1 | |
| SCHEMBL4482608 | 0.74 | ALDH1A1 (0.68) | HPGDALDH1A1CYP3A4MAPK1SMN1; SMN2 | |
| SCHEMBL4486903 | 0.74 | MEN1 (0.48) | HPGDALDH1A1CYP3A4TYMSKMT2A | |
| SCHEMBL7644570 | 0.70 | ALDH1A1 (0.44) | HPGDALDH1A1CYP3A4KMT2AMEN1 | |
| SCHEMBL2337883 | 0.69 | HPGD (0.58) | HPGDALDH1A1CYP3A4SMN1; SMN2KMT2A | |
| SCHEMBL2891489 | 0.69 | TYMP (0.52) | SMN1; SMN2 | |
| SCHEMBL4560955 | 0.69 | TYMP (0.52) | SMN1; SMN2 | |
| SCHEMBL25130124 | 0.69 | HPGD (0.68) | HPGDALDH1A1CYP3A4SMN1; SMN2KMT2A | |
| SCHEMBL6348563 | 0.68 | ALDH1A1 (0.62) | HPGDALDH1A1CYP3A4MAPK1SMN1; SMN2 | |
| SCHEMBL1032784 | 0.68 | HPGD (1.00) | HPGDALDH1A1CYP3A4SMN1; SMN2KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1385831-A2 | PYRIMIDINE COMPOUNDS AS ANTI-ICTOGENIC AND/OR ANTI-EPILEPTOGENIC AGENTS | QUEEN'S UNIVERSITY AT KINGSTON (CA) | 2004-02-04 | — | — | EP | disclosed |
| WO-2002083651-A2 | PYRIMIDINE COMPOUNDS AS ANTI-ICTOGENIC AND/OR ANTI-EPILEPTOGENIC AGENTS | QUEEN'S UNIVERSITY AT KINGSTON (CA) | 2002-10-24 | — | — | WO | disclosed |