Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.37 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.36 |
| ▸ | PARP1 | P09874 | 2/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.34 |
| ▸ | DRD3 | P35462 | 2/20 | 0.34 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.34 |
| ▸ | HTR1A | P08908 | 1/20 | 0.34 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.34 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.34 |
| ▸ | DRD1 | P21728 | 1/20 | 0.34 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.34 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.34 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.34 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6698166 | 0.91 | MEN1 (0.38) | MEN1KMT2ACYP3A4DRD3CHRM2 | |
| SCHEMBL6515535 | 0.86 | NR1H3 (0.46) | MEN1KMT2ALMNAKDM4EALDH1A1 | |
| SCHEMBL6515170 | 0.84 | NR1H3 (0.44) | MEN1KMT2AOPRM1KCNH2HRH3 | |
| SCHEMBL7073248 | 0.80 | LMNA (0.40) | MEN1KMT2ALMNAPOLBALDH1A1 | |
| SCHEMBL6515545 | 0.78 | NR1H3 (0.44) | MEN1KMT2AOPRM1KCNH2HRH3 | |
| SCHEMBL6510586 | 0.77 | NR1H3 (0.48) | MEN1KMT2AALDH1A1HRH3 | |
| SCHEMBL6512055 | 0.77 | NR1H3 (0.45) | MEN1KMT2AOPRM1KCNH2LMNA | |
| SCHEMBL6513610 | 0.76 | NR1H3 (0.45) | MEN1KMT2ALMNAKDM4EALDH1A1 | |
| SCHEMBL6519456 | 0.75 | NR1H3 (0.43) | CYP3A4DRD3CHRM2HTR1AADRA2A | |
| SCHEMBL6515146 | 0.74 | NR1H3 (0.55) | MEN1KMT2ALMNAKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2004509161-A | — | — | 2004-03-25 | — | — | JP | claimed |
| EP-1318976-A2 | SUBSTITUTED AMINOPROPOXYARYL DERIVATIVES USEFUL AS AGONISTS FOR LXR | GLAXO GROUP LIMITED (GB) | 2003-06-18 | — | — | EP | claimed |
| WO-2002024632-A2 | SUBSTITUTED AMINOPROPOXYARYL DERIVATIVES USEFUL AS AGONISTS FOR LXR | GLAXO GROUP LIMITED (GB) | 2002-03-28 | — | — | WO | claimed |