Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | NR1H3 | Q13133 | 7/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.39 |
| ▸ | TACR1 | P25103 | 1/20 | 0.38 |
| ▸ | HRH1 | P35367 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6698166 | 0.89 | MEN1 (0.38) | LMNAL3MBTL1TACR1ALDH1A1MEN1 | |
| SCHEMBL6513593 | 0.84 | NR1H3 (0.57) | NR1H3ALDH1A1MEN1KMT2A | |
| SCHEMBL6515354 | 0.80 | NR1H3 (0.54) | NR1H3 | |
| SCHEMBL6689959 | 0.80 | MEN1 (0.37) | LMNAL3MBTL1TACR1ALDH1A1MEN1 | |
| SCHEMBL6521358 | 0.76 | NR1H3 (0.57) | NR1H3ALDH1A1MEN1KMT2A | |
| SCHEMBL6511945 | 0.75 | NR1H3 (0.55) | LMNANR1H3HRH1ALDH1A1MEN1 | |
| SCHEMBL6515146 | 0.74 | NR1H3 (0.55) | LMNANR1H3ALDH1A1MEN1KMT2A | |
| SCHEMBL6520045 | 0.73 | NR1H3 (0.53) | LMNANR1H3ALDH1A1MEN1KMT2A | |
| SCHEMBL6515334 | 0.72 | NR1H3 (0.53) | NR1H3 | |
| SCHEMBL6566796 | 0.72 | NR1H3 (0.53) | NR1H3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1318976-A2 | SUBSTITUTED AMINOPROPOXYARYL DERIVATIVES USEFUL AS AGONISTS FOR LXR | GLAXO GROUP LIMITED (GB) | 2003-06-18 | — | — | EP | disclosed |
| WO-2002024632-A2 | SUBSTITUTED AMINOPROPOXYARYL DERIVATIVES USEFUL AS AGONISTS FOR LXR | GLAXO GROUP LIMITED (GB) | 2002-03-28 | — | — | WO | disclosed |