Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LIPG | Q9Y5X9 | 9/20 | 0.43 |
| ▸ | LPL | P06858 | 8/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.34 |
| ▸ | P4HB | P07237 | 1/20 | 0.33 |
| ▸ | LPAR1 | Q92633 | 3/20 | 0.33 |
| ▸ | ABCC3 | O15438 | 1/20 | 0.33 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.33 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.33 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | ABCB4 | P21439 | 1/20 | 0.33 |
| ▸ | ABCC2 | Q92887 | 1/20 | 0.33 |
| ▸ | SLCO1B3 | Q9NPD5 | 1/20 | 0.33 |
| ▸ | SLCO1B1 | Q9Y6L6 | 1/20 | 0.33 |
| ▸ | LPAR3 | Q9UBY5 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.32 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1379 | 0.82 | GAA (0.39) | GAALPAR1ABCC3ABCC4ABCB11 | |
| SCHEMBL6689 | 0.80 | LIPG (0.43) | LIPGLPLDGAT1TDP1 | |
| SCHEMBL17265478 | 0.75 | LIPG (0.41) | LIPGLPLDGAT1TDP1 | |
| SCHEMBL22408061 | 0.71 | LIPG (0.51) | LIPGLPLESR2MAPT | |
| SCHEMBL22467557 | 0.69 | LIPG (0.48) | LIPGLPLP4HBALDH1A1SMN1; SMN2 | |
| SCHEMBL2780544 | 0.69 | LPAR1 (0.74) | LIPGLPLP4HBLPAR1ABCC3 | |
| SCHEMBL12973569 | 0.69 | LPAR1 (0.74) | LIPGLPLP4HBLPAR1ABCC3 | |
| SCHEMBL2779479 | 0.68 | LIPG (0.46) | LIPGLPLP4HBLPAR1ABCC3 | |
| SCHEMBL28635541 | 0.66 | LIPG (0.45) | LIPGLPLDGAT1P4HBESR2 | |
| SCHEMBL1464 | 0.65 | GAA (0.38) | GAALPAR1ABCC3ABCC4ABCB11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2483252-A2 | COMPOUNDS AS LYSOPHOSPHATIDIC ACID RECEPTOR ANTAGONISTS | Amira Pharmaceuticals, Inc. (US) | 2012-08-08 | — | — | EP | disclosed |
| WO-2011041694-A2 | COMPOUNDS AS LYSOPHOSPHATIDIC ACID RECEPTOR ANTAGONISTS | AMIRA PHARMACEUTICALS, INC. (US) | 2011-04-07 | — | — | WO | disclosed |