Sugi Predict

Sugi Predict / Compounds / Proline

Proline

Proline

SCHEMBL6690171

C[C@H](N)C(=O)O.NCC(=O)OC(=O)CN.O=C(O)[C@@H]1CCCN1.O=C(OC1CCN[C@@H]1C(=O)O)[C@@H]1CCCN1

nearest known ligand 0.33

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

SLC5A2

The experimentally established mechanism targets of Proline. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
▸ MEN1 O00255 1/20 0.32
▸ BLM P54132 1/20 0.32
▸ KMT2A Q03164 1/20 0.32
▸ ARG1 P05089 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Threonine SCHEMBL6689276 0.92 — —
SCHEMBL4398036 0.85 MEN1 (0.35) MEN1BLMKMT2AARG1
Glycine SCHEMBL1675339 0.83 MEN1 (0.41) MEN1BLMKMT2AARG1
Glutamine SCHEMBL8704393 0.81 MEN1 (0.33) MEN1KMT2A
Glutamine SCHEMBL8700598 0.81 MEN1 (0.33) MEN1KMT2A
SCHEMBL1491950 0.80 MEN1 (0.47) MEN1BLMKMT2AARG1
Serine SCHEMBL5144903 0.80 MEN1 (0.36) MEN1BLMKMT2AARG1
Proline SCHEMBL1702869 0.77 NOS2 (0.37) MEN1BLMKMT2A
Proline SCHEMBL5860492 0.77 NOS2 (0.37) MEN1BLMKMT2A
Proline SCHEMBL3100537 0.77 NOS2 (0.37) MEN1BLMKMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2004110470-A2 USE OF COLLAGEN PEPTIDES TO INHIBIT INFECTION THE UNIVERSITY OF BRISTOL (GB) 2004-12-23 — — WO disclosed