SCHEMBL6691335

SCHEMBL6691335

Nc1cccc(N)c1-c1cccnc1

nearest known ligand 0.58

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP2A6 P11509 8/20 0.58
CYP3A4 P08684 4/20 0.58
ALDH1A1 P00352 2/20 0.58
CYP1A2 P05177 2/20 0.58
MKNK1 Q9BUB5 2/20 0.57
MKNK2 Q9HBH9 2/20 0.57
MEN1 O00255 1/20 0.57
PSIP1 O75475 1/20 0.57
AXL P30530 1/20 0.57
KDM4E B2RXH2 3/20 0.50
CYP2C9 P11712 3/20 0.50
SMN1; SMN2 Q16637 2/20 0.50
HTT P42858 2/20 0.50
HSD17B10 Q99714 2/20 0.50
LMNA P02545 2/20 0.50
CYP2E1 P05181 2/20 0.50
CYP2D6 P10635 2/20 0.50
CYP2B6 P20813 2/20 0.50
CYP2C19 P33261 2/20 0.50
TP53 P04637 1/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6172101 0.88 CYP2A6 (0.53) CYP2A6CYP3A4ALDH1A1CYP1A2MKNK1
SCHEMBL2936656 0.87 MKNK1 (0.49) CYP2A6CYP3A4ALDH1A1CYP1A2MKNK1
Hydrochloric Acid SCHEMBL2939932 0.85 MKNK1 (0.47) CYP2A6CYP3A4ALDH1A1CYP1A2MKNK1
SCHEMBL20240078 0.82 KDM4E (0.49) CYP2A6CYP3A4ALDH1A1CYP1A2MKNK1
SCHEMBL11965538 0.81 CYP2A6 (0.78) CYP2A6CYP3A4ALDH1A1CYP1A2MKNK1
SCHEMBL29535685 0.80 CYP2A6 (0.50) CYP2A6CYP3A4ALDH1A1CYP1A2MKNK1
SCHEMBL30279949 0.79 HPGDS (0.56) CYP2A6CYP3A4ALDH1A1CYP1A2MKNK1
SCHEMBL4082152 0.79 HPGDS (0.56) CYP2A6CYP3A4ALDH1A1CYP1A2MKNK1
SCHEMBL21476509 0.78 CYP2A6 (0.60) CYP2A6CYP3A4ALDH1A1CYP1A2MKNK1
SCHEMBL1956794 0.78 CYP2A6 (0.52) CYP2A6CYP3A4ALDH1A1CYP1A2MKNK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-1205179-C (P-aminohydroxyphenyl) acrylamide derivatives and coloring agents containing the same P & G CLAROLL CORP (US) 2005-06-08 CN claimed
CN-1437578-A (P-amino-hyaroxyphenyl)-acrylamide derivatives and dyes containing said compounds WELLA AG (DE) 2003-08-20 CN claimed
CN-101076571-A Cationic azoazine dyes and colorants containing said compounds PROCTER & GAMBLE (US) 2007-11-21 CN disclosed
WO-2004112736-A1 METHOD AND COMPOSITIONS FOR COLORING HAIR WITH TAURATE COPOLYMERS UNILEVER PLC (GB) 2004-12-29 WO disclosed
EP-0872903-B1 Method for making hydrogen storage alloy powder and electrode comprising the alloy powder SHINETSU CHEMICAL CO (JP) 2001-10-04 EP disclosed
US-6277519-B1 QUENCHING AN ALLOY MELT; COMMINUTION SHIN-ETSU CHEMICAL CO., LTD. (JP) 2001-08-21 US disclosed
US-6096144-A TREATING WITH ACIDIC OR ALKALINE SOLUTION OF CONJUGATED UNSATURATED COMPOUND WITH AT LEAST 5 BONDS SHIN-ETSU CHEMICAL CO., LTD. (JP) 2000-08-01 US disclosed
US-5858571-A TREATING A PULVERIZED HYDROGEN ABSORBING ALLOY WITH A SOLUTION COMPRISING A CONJUGATED UNSATURATED COMPOUND SHIN-ETSU CHEMICAL CO., LTD. (JP) 1999-01-12 US disclosed
EP-0872903-A1 Method for making hydrogen storage alloy powder and electrode comprising the alloy powder Shin-Etsu Chemical Co., Ltd. (JP) 1998-10-21 EP disclosed
CN-1006386-B PROCESS FOR PRODUCTION OF VINYL CHLORIDE POLYMER SHINETSU CHEM IND CO (JP) 1990-01-10 CN disclosed
EP-0172427-B1 PROCESS FOR PRODUCTION OF VINYL CHLORIDE POLYMER Shin-Etsu Chemical Co., Ltd. (JP) 1989-07-05 EP disclosed
US-4758639-A Process for production of vinyl polymer SHIN-ETSU CHEMICAL CO., LTD. (JP) 1988-07-19 US disclosed
US-4757124-A Suspension or emulsion polymerizing vinyl chloride monomer or mixture of vinyl chloride with vinyl monomer copolymerizable therewith in reactor with walls coated with antiscaling compound containing dye or pigments SHIN-ETSU CHEMICAL CO., LTD. (JP) 1988-07-12 US disclosed
CN-85107531-A Process for producing vinyl chloride polymer 1987-01-21 CN disclosed
EP-0172427-A2 Process for production of vinyl chloride polymer Shin-Etsu Chemical Co., Ltd. (JP) 1986-02-26 EP disclosed
US-4229456-A SUPPRESSION OF GASTRIC SECRETIONS MERCK & CO., INC. (US) 1980-10-21 US disclosed
US-4133885-A GASTRIC SECRETIONS INHIBITORS MERCK & CO., INC. (US) 1979-01-09 US disclosed