Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.35 |
| ▸ | POLB | P06746 | 2/20 | 0.35 |
| ▸ | NPC1 | O15118 | 2/20 | 0.35 |
| ▸ | RAB9A | P51151 | 2/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | PLAU | P00749 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | BLM | P54132 | 2/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.33 |
| ▸ | F2 | P00734 | 1/20 | 0.33 |
| ▸ | F10 | P00742 | 1/20 | 0.33 |
| ▸ | F12 | P00748 | 1/20 | 0.33 |
| ▸ | F7 | P08709 | 1/20 | 0.33 |
| ▸ | F3 | P13726 | 1/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Biguanide SCHEMBL28252577 | 0.85 | MEN1 (0.45) | NPSR1ALDH1A1KMT2ANPC1RAB9A | |
| SCHEMBL725723 | 0.81 | ALDH1A1 (0.36) | NPSR1ALDH1A1KMT2APLAUMEN1 | |
| Hydrochloric Acid SCHEMBL7199219 | 0.80 | BLM (0.38) | ALDH1A1KMT2AMEN1BLMF2 | |
| SCHEMBL6695684 | 0.79 | PLAU (0.38) | NPSR1ALDH1A1KMT2APOLBPLAU | |
| SCHEMBL28515349 | 0.79 | NPSR1 (0.36) | NPSR1ALDH1A1KMT2APOLBRAB9A | |
| SCHEMBL6699643 | 0.79 | NPSR1 (0.36) | NPSR1ALDH1A1KMT2APOLBHTT | |
| SCHEMBL2913044 | 0.76 | TDP1 (0.47) | NPSR1ALDH1A1KMT2ANPC1RAB9A | |
| SCHEMBL27666370 | 0.76 | NPSR1 (0.38) | NPSR1ALDH1A1KMT2APOLBNPC1 | |
| SCHEMBL11449286 | 0.75 | NPSR1 (0.43) | NPSR1ALDH1A1KMT2APOLBNPC1 | |
| SCHEMBL2068767 | 0.75 | NPSR1 (0.43) | NPSR1ALDH1A1KMT2APOLBNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-3553083-B2 | — | — | 2004-08-11 | — | — | JP | claimed |
| EP-1019051-A4 | PERIPHERALLY ACTING ANTI-PRURITIC OPIATES | ADOLOR CORP (US) | 2003-05-28 | — | — | EP | claimed |
| EP-1119354-A4 | PERIPHERALLY ACTING ANTI-PRURITIC OPIATES | ADOLOR CORP (US) | 2003-02-12 | — | — | EP | claimed |
| JP-2002527392-A | — | — | 2002-08-27 | — | — | JP | claimed |
| EP-1119354-A1 | PERIPHERALLY ACTING ANTI-PRURITIC OPIATES | Adolor Corporation (US) | 2001-08-01 | — | — | EP | claimed |
| JP-2001510157-A | — | — | 2001-07-31 | — | — | JP | claimed |
| EP-1019051-A1 | PERIPHERALLY ACTING ANTI-PRURITIC OPIATES | Adolor Corporation (US) | 2000-07-19 | — | — | EP | claimed |
| WO-2000021530-A1 | PERIPHERALLY ACTING ANTI-PRURITIC OPIATES | ADOLOR CORPORATION (US) | 2000-04-20 | — | — | WO | claimed |
| WO-1999003472-A1 | PERIPHERALLY ACTING ANTI-PRURITIC OPIATES | ADOLOR CORPORATION (US) | 1999-01-28 | — | — | WO | claimed |
| EP-0852494-A2 | PERIPHERALLY ACTIVE ANTI-HYPERALGESIC OPIATES | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 1998-07-15 | — | — | EP | claimed |
| WO-1997009973-A2 | PERIPHERALLY ACTIVE ANTI-HYPERALGESIC OPIATES | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 1997-03-20 | — | — | WO | claimed |