Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | GPR17 | Q13304 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | RXRG | P48443 | 7/20 | 0.37 |
| ▸ | RXRA | P19793 | 6/20 | 0.37 |
| ▸ | RXRB | P28702 | 6/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.36 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.36 |
| ▸ | SRC | P12931 | 1/20 | 0.36 |
| ▸ | KDR | P35968 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | CASP6 | P55212 | 1/20 | 0.35 |
| ▸ | PARP1 | P09874 | 1/20 | 0.34 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6299779 | 0.98 | NPSR1 (0.42) | NPSR1HPGDGPR17CYP2C19RXRG | |
| SCHEMBL6695442 | 0.78 | GPR17 (0.40) | NPSR1HPGDGPR17CYP2C19TSHR | |
| SCHEMBL3797505 | 0.75 | GPR17 (0.40) | NPSR1HPGDGPR17CYP2C19TSHR | |
| SCHEMBL5405308 | 0.75 | FKBP1A (0.47) | NPSR1HPGDTSHRKMT2AKDM4E | |
| SCHEMBL1369026 | 0.74 | HTR1D (0.43) | NPSR1PARP1 | |
| SCHEMBL20842318 | 0.72 | KMT2A (0.48) | NPSR1HPGDCYP2C19TSHRKMT2A | |
| SCHEMBL6697504 | 0.70 | SLC6A4 (0.44) | SRCPARP1 | |
| SCHEMBL7880947 | 0.69 | GPR17 (0.38) | NPSR1HPGDGPR17CYP2C19PDGFRB | |
| SCHEMBL22289913 | 0.68 | GFER (0.46) | HPGDTSHRKMT2AKDM4EMEN1 | |
| SCHEMBL6407362 | 0.68 | SLC6A4 (0.45) | SRCPARP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040186160-A1 | Hexahydro-cyclohepta-pyrrole oxindole as potent kinase inhibitors | SUGEN, INC. | 2004-09-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040186160-A1 | Hexahydro-cyclohepta-pyrrole oxindole as potent kinase inhibitors | MAP3K15, MAP3K20, MAP3K19 | NPSR1 2687/4885HPGD 1104/4885GPR17 1157/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.