Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR17 | Q13304 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | PARP1 | P09874 | 1/20 | 0.33 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.30 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.30 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.30 |
| ▸ | KDR | P35968 | 1/20 | 0.30 |
| ▸ | ZAP70 | P43403 | 1/20 | 0.30 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12536197 | 0.79 | KDM4E (0.41) | HPGD | |
| SCHEMBL14300543 | 0.78 | HTR2A (0.35) | PARP1 | |
| SCHEMBL7051131 | 0.77 | — | — | |
| SCHEMBL6299779 | 0.70 | NPSR1 (0.42) | GPR17HPGDCYP2C19NPSR1PARP1 | |
| SCHEMBL6691776 | 0.69 | NPSR1 (0.41) | GPR17HPGDCYP2C19NPSR1PARP1 | |
| SCHEMBL13542070 | 0.64 | — | — | |
| SCHEMBL28737712 | 0.64 | NPSR1 (0.54) | GPR17HPGDCYP2C19NPSR1PARP1 | |
| SCHEMBL18738896 | 0.64 | GPR17 (0.38) | GPR17HPGDCYP2C19NPSR1PARP1 | |
| SCHEMBL1171886 | 0.61 | NPSR1 (0.52) | GPR17HPGDCYP2C19NPSR1PARP1 | |
| SCHEMBL3797505 | 0.61 | GPR17 (0.40) | GPR17HPGDCYP2C19NPSR1PARP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010136474-A2 | SUBSTITUTED AMINOBUTYRIC DERIVATIVES AS NEPRILYSIN INHIBITORS | NOVARTIS AG (CH) | 2010-12-02 | — | — | WO | disclosed |
| WO-2008005368-A2 | PIPERAZINES AS P2X7 ANTAGONISTS | ABBOTT LABORATORIES (US) | 2008-01-10 | — | — | WO | disclosed |