Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 6/20 | 0.43 |
| ▸ | SCD | O00767 | 1/20 | 0.41 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.41 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.40 |
| ▸ | CBFB | Q13951 | 1/20 | 0.40 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.39 |
| ▸ | GRIA3 | P42263 | 1/20 | 0.39 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.39 |
| ▸ | IKBKB | O14920 | 1/20 | 0.37 |
| ▸ | CHUK | O15111 | 1/20 | 0.37 |
| ▸ | BRD4 | O60885 | 1/20 | 0.36 |
| ▸ | GCK | P35557 | 1/20 | 0.36 |
| ▸ | PTGES | O14684 | 1/20 | 0.35 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2918049 | 0.87 | GRIA1 (0.47) | GRIA1GRIA3PDE4D | |
| Water SCHEMBL4777584 | 0.87 | GRIA1 (0.47) | GRIA1GRIA3PDE4D | |
| SCHEMBL6686812 | 0.83 | GRIA1 (0.47) | GRIA1GRIA3PDE4D | |
| SCHEMBL6674051 | 0.82 | PARP1 (0.39) | GRIA1GRIA3PDE4D | |
| SCHEMBL1882884 | 0.80 | GRIA1 (0.47) | TGFBR1GRIA1GRIA3PDE4D | |
| SCHEMBL6680176 | 0.79 | LRRK2 (0.44) | GRIA1GRIA3PDE4DIKBKBCHUK | |
| SCHEMBL6677166 | 0.78 | GRIA1 (0.40) | GRIA1GRIA3PDE4D | |
| SCHEMBL6689989 | 0.78 | KDM4E (0.43) | CBFBGRIA1GRIA3PDE4D | |
| SCHEMBL6698453 | 0.77 | GRIA1 (0.47) | TGFBR1GRIA1GRIA3PDE4D | |
| SCHEMBL2762970 | 0.77 | MCL1 (0.50) | TGFBR1GRIA1GRIA3PDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1465626-A2 | PHARMACEUTICAL COMPOSITIONS COMPRISING DIHYDROPYRIDINONE COMPOUNDS AND AN IMMUNOREGULATORY OR AN ANTIINFLAMMATORY AGENT AND THEIR USES | Eisai Co., Ltd. (JP) | 2004-10-13 | — | — | EP | disclosed |
| WO-2003047577-A2 | PHARMACEUTICAL COMPOSITIONS COMPRISING DIHYDROPYRIDINONE COMPOUNDS AND AN IMMUNOREGULATORY OR AN ANTIINFLAMMATORY AGENT AND THEIR USES | EISAI CO LTD (JP) | 2003-06-12 | — | — | WO | disclosed |