Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.44 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.41 |
| ▸ | GRIA3 | P42263 | 1/20 | 0.41 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.41 |
| ▸ | CDC7 | O00311 | 1/20 | 0.39 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.38 |
| ▸ | CDK2 | P24941 | 1/20 | 0.38 |
| ▸ | MCL1 | Q07820 | 3/20 | 0.38 |
| ▸ | RAF1 | P04049 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.37 |
| ▸ | PIM1 | P11309 | 2/20 | 0.37 |
| ▸ | IKBKB | O14920 | 1/20 | 0.36 |
| ▸ | CHUK | O15111 | 1/20 | 0.36 |
| ▸ | KDM1A | O60341 | 1/20 | 0.35 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.35 |
| ▸ | FASN | P49327 | 1/20 | 0.35 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Water SCHEMBL4777584 | 0.88 | GRIA1 (0.47) | LRRK2GRIA1GRIA3PDE4DMCL1 | |
| SCHEMBL2918049 | 0.88 | GRIA1 (0.47) | LRRK2GRIA1GRIA3PDE4DMCL1 | |
| SCHEMBL6677166 | 0.85 | GRIA1 (0.40) | LRRK2GRIA1GRIA3PDE4DMCL1 | |
| SCHEMBL6686812 | 0.84 | GRIA1 (0.47) | LRRK2GRIA1GRIA3PDE4DMCL1 | |
| SCHEMBL1882884 | 0.82 | GRIA1 (0.47) | LRRK2GRIA1GRIA3PDE4DMCL1 | |
| SCHEMBL6692587 | 0.82 | CTSL (0.40) | LRRK2GRIA1GRIA3PDE4DALDH1A1 | |
| SCHEMBL6698453 | 0.80 | GRIA1 (0.47) | LRRK2GRIA1GRIA3PDE4DMCL1 | |
| SCHEMBL2762970 | 0.80 | MCL1 (0.50) | LRRK2GRIA1GRIA3PDE4DMCL1 | |
| SCHEMBL6674535 | 0.80 | ESR2 (0.40) | LRRK2MCL1KDM4EALDH1A1HPGD | |
| SCHEMBL6691807 | 0.79 | PTGS2 (0.43) | GRIA1GRIA3PDE4DIKBKBCHUK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1465626-A2 | PHARMACEUTICAL COMPOSITIONS COMPRISING DIHYDROPYRIDINONE COMPOUNDS AND AN IMMUNOREGULATORY OR AN ANTIINFLAMMATORY AGENT AND THEIR USES | Eisai Co., Ltd. (JP) | 2004-10-13 | — | — | EP | disclosed |
| WO-2003047577-A2 | PHARMACEUTICAL COMPOSITIONS COMPRISING DIHYDROPYRIDINONE COMPOUNDS AND AN IMMUNOREGULATORY OR AN ANTIINFLAMMATORY AGENT AND THEIR USES | EISAI CO LTD (JP) | 2003-06-12 | — | — | WO | disclosed |